Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate

Base Information

• Chemical Name: Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate
• CAS No.: 231297-24-8
• Molecular Formula: C₂₂H₁₈Cl₃NO₅
• Molecular Weight: 482.748
• Mol file: 231297-24-8.mol

Synonyms:

Chemical Property of Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate

There total 5 articles about Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl malonate (105-53-3) → Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate (231297-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; manganese(III) triacetate dihydrate / 20 - 80 °C / Inert atmosphere

2: trifluoroacetic acid; triethylsilane / dichloromethane / Inert atmosphere; Reflux

With triethylsilane; manganese(III) triacetate dihydrate; acetic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.3109/14756366.2013.864650

Reference yield:

6-chloroindole (17422-33-2) → Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate (231297-24-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / water; benzene / 0.17 h / 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / -78 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

3.1: water / tetrahydrofuran / Reflux; Inert atmosphere; Alkaline conditions

4.1: acetic acid; manganese(III) triacetate dihydrate / 20 - 80 °C / Inert atmosphere

5.1: trifluoroacetic acid; triethylsilane / dichloromethane / Inert atmosphere; Reflux

With triethylsilane; water; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; manganese(III) triacetate dihydrate; acetic acid; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; pentane; benzene;

DOI:10.3109/14756366.2013.864650

Reference yield:

6-chloro-2-(2,4-dichlorobenzoyl)-1-(phenylsulfonyl)indole (231297-18-0) → Diethyl[6-chloro-2-(2,4-dichlorobenzoyl)-1H-indol-3-yl]malonate (231297-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1: water / tetrahydrofuran / Reflux; Inert atmosphere; Alkaline conditions

2: acetic acid; manganese(III) triacetate dihydrate / 20 - 80 °C / Inert atmosphere

3: trifluoroacetic acid; triethylsilane / dichloromethane / Inert atmosphere; Reflux

With triethylsilane; water; manganese(III) triacetate dihydrate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.3109/14756366.2013.864650

upstream raw materials:

diethyl malonate

6-chloro-2-(2,4-dichlorobenzoyl)-1-(phenylsulfonyl)indole

6-chloroindole

6-chloro-2-(2,4-dichlorobenzoyl)indole