S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate

Base Information

Chemical Name:S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate
CAS No.:1392223-12-9
Molecular Formula:C₃₈H₄₇N₃O₁₁S
Molecular Weight:753.871
Hs Code.:

S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate

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Chemical Property of S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate

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Technology Process of S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate

There total 6 articles about S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392223-11-8
2-(4-mercaptophenyl)-N-(4-nitrobenzyl)acetamide

: 1392223-14-1
C₂₃H₃₅NO₉

: 1392223-12-9
S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate

Guidance literature:: With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1002/anie.201200867

Reference yield:

: 883566-52-7
2-(4-(triphenylmethylthio)phenyl)acetic acid

: 1392223-12-9
S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

2: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 5 h / 20 °C

With dmap; chlorotriisopropylsilane; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200867

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1392223-12-9
S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate

Guidance literature:: Multi-step reaction with 6 steps

1: phosphorus pentoxide / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / 95 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 0 °C

4: potassium fluoride; palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 170 °C / Microwave irradiation

5: sodium hydroxide / water; N,N-dimethyl-formamide

6: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 5 h / 20 °C

With dmap; potassium fluoride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); phosphorus pentoxide; palladium diacetate; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200867