(-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

Base Information

Chemical Name:(-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline
CAS No.:906664-50-4
Molecular Formula:C₂₈H₃₂N₂O₅
Molecular Weight:476.572
Hs Code.:

(-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

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Chemical Property of (-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

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Technology Process of (-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

There total 1 articles about (-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 547-65-9
α-methylene-γ-butyrolactone

: 831176-42-2
N-benzyl-N-(tert-butoxycarbonyl)-2-(2-oxo-1,2-dihydroquinolin-4-yl)ethylamine

: (1R,2aR,8bS)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

: 906664-50-4
(-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

Guidance literature:: With chiral complexing agent; In toluene; at -60 ℃; Title compound not separated from byproducts; Irradiation;
DOI:10.1021/jo0606608

Reference yield:

: 906664-50-4
(-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

: C₂₃H₂₄N₂O₃

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;
DOI:10.1021/jo0606608

Reference yield:

: 906664-50-4
(-)-(1S,2aS,8bR)-8b-{2-[benzyl(tert-butoxycarbonyl)amino]ethyl}-1-[spiro-(4-γ-butyro-lactonyl)]-3-oxo-1,2,2a,3,4,8b-hexahydrocyclobuta[c]quinoline

: (+)-(1aS,7bS,11aS)-10-benzyl-11a-ethyl-1,9,10,11a-tetrahydro-1aH-pyrido[4',3':2,3']-cyclobuta[1,2-c]quinoline-2,11(3H,8H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 2 h

2: 0.33 h / 200 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo0606608