1-(DiMethylsulfaMoyl)pyrazole

Base Information

• Chemical Name: 1-(DiMethylsulfaMoyl)pyrazole
• CAS No.: 133228-21-4
• Molecular Formula: C5H9N3O2S
• Molecular Weight: 175.211
• Hs Code.: 2935009090
• Mol file: 133228-21-4.mol

Synonyms:pyrazole-1-sulfonic acid dimethylamide;pyrazole-1-sulphonic acid dimethylamide;N,N-dimethylpyrazole-1-sulfonamide;

Chemical Property of 1-(DiMethylsulfaMoyl)pyrazole

Chemical Property:

• Melting Point: 118.5 °C
• Boiling Point: 287.4±23.0 °C(Predicted)
• PKA: -2.65±0.12(Predicted)
• PSA: 63.58000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 0.61840
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(Dimethylsulfamoyl)pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(DiMethylsulfaMoyl)pyrazole

There total 3 articles about 1-(DiMethylsulfaMoyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

NH-pyrazole (288-13-1) + dimethylamino sulfonyl chloride (13360-57-1) → N,N-dimethyl-1H-pyrazole-1-sulfonamide (133228-21-4)

Guidance literature:

NH-pyrazole; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

dimethylamino sulfonyl chloride; In tetrahydrofuran; for 1.5h;

DOI:10.1055/s-2006-926319

Reference yield: 82.0%

dimethylamino sulfonyl chloride (13360-57-1) → N,N-dimethyl-1H-pyrazole-1-sulfonamide (133228-21-4)

Guidance literature:

NH-pyrazole; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

dimethylamino sulfonyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

→ N,N-dimethyl-1H-pyrazole-1-sulfonamide (133228-21-4)

Guidance literature:

upstream raw materials:

NH-pyrazole

dimethylamino sulfonyl chloride

Downstream raw materials:

N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-sulfonamide

3-(1-(N,N-dimethylsulfamoyl)-1H-pyrazol-5-yl)-N,N-diethylbenzamide

5-(3,5-bis(trifluoromethyl)phenyl)-N,N-dimethyl-1H-pyrazole-1-sulfonamide

5-(3-acetylphenyl)-N,N-dimethyl-1H-pyrazole-1-sulfonamide