2-(4-Fluorophenyl)-2,5-dimethylfuran-3(2H)-one

Base Information

Chemical Name:2-(4-Fluorophenyl)-2,5-dimethylfuran-3(2H)-one
CAS No.:133255-54-6
Molecular Formula:C12H11FO2
Molecular Weight:206.217
Hs Code.:
DSSTox Substance ID:DTXSID90568008
Nikkaji Number:J1.917.481F

Synonyms:133255-54-6;2-(4-Fluorophenyl)-2,5-dimethylfuran-3(2H)-one;2,5-dimethyl-2-(4-fluorophenyl)-3(2H)-furanone;SCHEMBL9866953;DTXSID90568008;HQFRYBRGHSVFHA-UHFFFAOYSA-N;2,5-dimethyl-2-(4-fluorphenyl)-3(2H)-furanone

Suppliers and Price of 2-(4-Fluorophenyl)-2,5-dimethylfuran-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-(4-Fluorophenyl)-2,5-dimethylfuran-3(2H)-one

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:206.07430775
Heavy Atom Count:15
Complexity:303

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)C(O1)(C)C2=CC=C(C=C2)F

Technology Process of 2-(4-Fluorophenyl)-2,5-dimethylfuran-3(2H)-one

There total 4 articles about 2-(4-Fluorophenyl)-2,5-dimethylfuran-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 138958-57-3
1-(4-fluorophenyl)-1-(3-methyl-5-isoxazolyl)-1-ethanol

: 133255-54-6
2-methyl-2-(4-fluorophenyl)-5-methyl-3(2H)-furanone

Guidance literature:: 1-(4-fluorophenyl)-1-(3-methyl-5-isoxazolyl)-1-ethanol; With hydrogen; palladium on activated charcoal; In methanol; for 10h;

With hydrogenchloride; In water; for 3h;
DOI:10.1016/S0040-4020(03)00776-2

Reference yield:

: 55086-61-8
5-acetyl-3-methylisoxazole

: 133255-54-6
2-methyl-2-(4-fluorophenyl)-5-methyl-3(2H)-furanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / diethyl ether / 0.5 h / 0 °C

2.1: hydrogen / Pd/C / methanol / 10 h

2.2: 63 percent / aqueous hydrochloric acid / H₂O / 3 h

With hydrogen; palladium on activated charcoal; In methanol; diethyl ether; 1.1: Grignard reaction;
DOI:10.1016/S0040-4020(03)00776-2

Reference yield:

: 71502-43-7
(3-methyl-5-isoxazolyl)-1-ethanol

: 133255-54-6
2-methyl-2-(4-fluorophenyl)-5-methyl-3(2H)-furanone

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / CrO₃, 6 N aq. H₂SO₄ / H₂O; acetone / 0 - 20 °C

2: 91 percent / diethyl ether / 0.5 h

3: 1.) H₂, 2.) 1 N aq. HCl / 1.) 10percent Pd/C / 1.) CH₃OH, 20 psi, 2.) CH₃OH, 1h

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; hydrogen; palladium on activated charcoal; In diethyl ether; water; acetone;
DOI:10.1021/jm00085a003