Febuxostat Impurity 14

Base Information

Chemical Name:Febuxostat Impurity 14
CAS No.:1335202-60-2
Molecular Formula:C₁₅H₁₆N₂OS
Molecular Weight:272.371
Hs Code.:
Mol file:1335202-60-2.mol

Synonyms:

Suppliers and Price of Febuxostat Impurity 14

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DescarboxylFebuxostat
5mg
$ 405.00

TRC
DescarboxylFebuxostat
2.5mg
$ 215.00

TRC
DescarboxylFebuxostat
10mg
$ 765.00

American Custom Chemicals Corporation
2-ISOBUTOXY-5-(4-METHYLTHIAZOL-2-YL) BENZONITRILE 95.00%
5MG
$ 497.15

Total 12 raw suppliers

Chemical Property of Febuxostat Impurity 14

Chemical Property:

Melting Point:84-86°C
Boiling Point:435.5±55.0 °C(Predicted)
PKA:2.48±0.10(Predicted)
Density:1.17±0.1 g/cm3(Predicted)
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

DescarboxylFebuxostat ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Descarboxyl Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.

Technology Process of Febuxostat Impurity 14

There total 3 articles about Febuxostat Impurity 14 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 78-77-3
Isobutyl bromide

: 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole

: 1335202-60-2
2-(2-methylpropoxy)-5-(4-methyl-1,3-thiazol-2-yl) benzonitrile

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 65 - 75 ℃; for 8h;

Reference yield:

: 25984-63-8
4-hydroxythiobenzamide

: 1335202-60-2
2-(2-methylpropoxy)-5-(4-methyl-1,3-thiazol-2-yl) benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / Reflux

2: hexamethylenetetramine / 52 h / Reflux

3: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 65 - 75 °C

With formic acid; hexamethylenetetramine; hydroxylamine hydrochloride; sodium formate; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;

Reference yield:

: 138330-01-5
4-(4-methyl-thiazol-2-yl)-phenol

: 1335202-60-2
2-(2-methylpropoxy)-5-(4-methyl-1,3-thiazol-2-yl) benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hexamethylenetetramine / 52 h / Reflux

2: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 65 - 75 °C

With formic acid; hexamethylenetetramine; hydroxylamine hydrochloride; sodium formate; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;