C₂₇H₃₀F₂N₂O₃

Base Information

• Chemical Name: C₂₇H₃₀F₂N₂O₃
• CAS No.: 1345968-28-6
• Molecular Formula: C₂₇H₃₀F₂N₂O₃
• Molecular Weight: 468.544

Synonyms:

Chemical Property of C₂₇H₃₀F₂N₂O₃

Chemical Property:

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Technology Process of C₂₇H₃₀F₂N₂O₃

There total 7 articles about C₂₇H₃₀F₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H28F2N2O4 → C27H30F2N2O3 (1345968-27-5) + C27H30F2N2O3 (1345968-28-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 60 ℃;

DOI:10.1016/j.bmcl.2011.06.116

Reference yield:

C25H29F2NO6 → C27H30F2N2O3 (1345968-28-6)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide / toluene

2: trifluoroacetic acid / dichloromethane / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

4: sodium hydroxide / ethanol / 60 °C

With diphenyl phosphoryl azide; sodium tris(acetoxy)borohydride; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; toluene; 1: Curtius rearrangement;

DOI:10.1016/j.bmcl.2011.06.116

Reference yield:

(S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one (877078-49-4) → C27H30F2N2O3 (1345968-28-6)

Guidance literature:

Multi-step reaction with 6 steps

1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C

2: lithium hydroperoxide / tetrahydrofuran; water / 0 - 20 °C

3: diphenyl phosphoryl azide / toluene

4: trifluoroacetic acid / dichloromethane / 20 °C

5: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

6: sodium hydroxide / ethanol / 60 °C

With lithium hydroperoxide; di-n-butylboryl trifluoromethanesulfonate; diphenyl phosphoryl azide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 3: Curtius rearrangement;

DOI:10.1016/j.bmcl.2011.06.116

upstream raw materials:

(S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one

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