Technology Process of 2-[(2-chlorophenyl)iminomethyl]-4,5-difluorophenylamine
There total 1 articles about 2-[(2-chlorophenyl)iminomethyl]-4,5-difluorophenylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,4-difluoroaniline;
With
boron trichloride;
In
toluene;
at 0 - 20 ℃;
for 3h;
2-Chlorobenzonitrile;
With
gallium(III) trichloride;
In
toluene;
for 18h;
Reflux;
DOI:10.1021/ml300351e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium methylate / tert-Amyl alcohol / 18 h / Reflux
2.1: acetic acid / isopropyl alcohol / 18 h / Reflux
3.1: 1,2,4-Triazole; N-ethyl-N,N-diisopropylamine; trichlorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: sodium methylate / tetrahydrofuran / 18 h / 20 °C
5.1: N,N-dimethylacetamide dimethyl acetal / N,N-dimethyl-formamide / 24 h / 130 °C
5.2: 24 h / 25 °C
With
1,2,4-Triazole; N,N-dimethylacetamide dimethyl acetal; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
tetrahydrofuran; tert-Amyl alcohol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/ml300351e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium methylate / tert-Amyl alcohol / 18 h / Reflux
2: acetic acid / isopropyl alcohol / 18 h / Reflux
With
sodium methylate; acetic acid;
In
tert-Amyl alcohol; isopropyl alcohol;
DOI:10.1021/ml300351e
