5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one

Base Information

• Chemical Name: 5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one
• CAS No.: 882531-54-6
• Molecular Formula: C₁₆H₁₂ClFN₂O₂
• Molecular Weight: 318.735
• Mol file: 882531-54-6.mol

Synonyms:5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one

Chemical Property of 5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one

There total 12 articles about 5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

2-[(2-chlorophenyl)(imino)methyl]-4-fluoro-5-methoxyphenylamine (1420683-72-2) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → 5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one (882531-54-6)

Guidance literature:

With acetic acid; In isopropyl alcohol; for 18h; Reflux;

DOI:10.1021/ml300351e

Reference yield:

2-(N,N-Diallylamino)-2'-(2-chlorobenzoyl)-4'-fluoro-5'-methoxyacetanilide (1178859-04-5) → 5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one (882531-54-6)

Guidance literature:

With 1,3-dimethylbarbituric acid; acetic acid; palladium diacetate; triphenylphosphine; In isopropyl alcohol; at 25 - 76 ℃; Product distribution / selectivity;

Reference yield:

5-(2-Chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepine-2-one (882531-54-6) → C16H12ClFN2O2 (882531-54-6)

Guidance literature:

With 1,2,4-Triazole; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1021/ml300351e

upstream raw materials:

(2-amino-5-fluoro-4-methoxyphenyl)(2-chlorophenyl)methanone

methanol

5-(2-chlorophenyl)-7,8-difluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one

2-(N,N-Diallylamino)-2'-(2-chlorobenzoyl)-4'-fluoro-5'-methoxyacetanilide

Downstream raw materials:

5-(2-chlorophenyl)-1,3-dihydro-7-fluoro-8-methoxy-2H-1,4-benzodiazepin-2-thione

5-(2-chlorophenyl)-7-fluoro-2,8-dimethoxy-3H-benzo[e][1,4]diazepine

R₁₅₃₀