4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

Base Information

Chemical Name:4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate
CAS No.:1332729-41-5
Molecular Formula:C₅₅H₅₃N₆O₁₅P
Molecular Weight:1069.03
Hs Code.:

4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

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Chemical Property of 4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

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Technology Process of 4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

There total 6 articles about 4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332729-29-9
diisopropyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

: 1332729-41-5
4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine; trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

2: pyridine; dicyclohexyl-carbodiimide / 72 h / 20 °C

3: pyridine; water / 16 h / 50 °C

With pyridine; 2,6-dimethylpyridine; trimethylsilyl bromide; water; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1039/c1ob05488k

Reference yield:

: C₆₂H₆₀N₇O₁₇P

: 1332729-41-5
4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

Guidance literature:: With pyridine; water; at 50 ℃; for 16h;
DOI:10.1039/c1ob05488k

Reference yield:

: benzoyloxymethoxymethyl chloride

: 1332729-41-5
4-methoxy-1-oxido-2-pyridylmethyl [1-(6-N-benzoyladenin-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibutyltin chloride; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 3 h / 85 °C

1.3: 16 h / 20 °C

2.1: 2,6-dimethylpyridine; trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

3.1: pyridine; dicyclohexyl-carbodiimide / 72 h / 20 °C

4.1: pyridine; water / 16 h / 50 °C

With pyridine; 2,6-dimethylpyridine; trimethylsilyl bromide; dibutyltin chloride; water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1039/c1ob05488k