Technology Process of 2-(4-bromophenyl)-N-methoxy-1H-indole-1-carboxamide
There total 4 articles about 2-(4-bromophenyl)-N-methoxy-1H-indole-1-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate;
In
methanol;
at 60 ℃;
for 3h;
Mechanism;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/ol5014312
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere
1.2: 1 h / 0 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2.5 h / 0 - 20 °C
3.1: sodium hydrogencarbonate / ethanol; water / 0 °C
3.2: 5.5 h / 0 - 20 °C
4.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate / methanol / 3 h / 60 °C / Schlenk technique; Inert atmosphere
With
n-butyllithium; oxalyl dichloride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; sodium hydrogencarbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1021/ol5014312
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2.5 h / 0 - 20 °C
2.1: sodium hydrogencarbonate / ethanol; water / 0 °C
2.2: 5.5 h / 0 - 20 °C
3.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate / methanol / 3 h / 60 °C / Schlenk technique; Inert atmosphere
With
oxalyl dichloride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; sodium hydrogencarbonate; N,N-dimethyl-formamide;
In
methanol; ethanol; dichloromethane; water;
DOI:10.1021/ol5014312
