(R)-2-nitro-1-phenylethyl acetate

Base Information

• Chemical Name: (R)-2-nitro-1-phenylethyl acetate
• CAS No.: 1336918-22-9
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Mol file: 1336918-22-9.mol

Synonyms:

Chemical Property of (R)-2-nitro-1-phenylethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-nitro-1-phenylethyl acetate

There total 2 articles about (R)-2-nitro-1-phenylethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 2-nitro-1-phenylethan-1-ol (141377-54-0,145920-96-3,149495-00-1,15990-45-1) → (R)-2-nitro-1-phenylethyl acetate (1336918-22-9) + (S)-1-phenyl-2-nitroethanol (149495-00-1)

Guidance literature:

With amano lipase PS-IM immobilized on diatomaceous earth; In toluene; at 25 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c1gc15417f

Reference yield:

benzaldehyde (100-52-7) → (R)-2-nitro-1-phenylethyl acetate (1336918-22-9) + (S)-1-phenyl-2-nitroethanol (149495-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Ca²⁺-crosslinked alginate hydrogel beads / dimethyl sulfoxide / 24 h / 20 °C / Green chemistry

2: amano lipase PS-IM / toluene / 18 h / 20 °C

With amano lipase PS-IM; In dimethyl sulfoxide; toluene; 1: |Henry Nitro Aldol Condensation;

DOI:10.1039/c4nj02178a

upstream raw materials:

vinyl acetate

2-nitro-1-phenylethan-1-ol

benzaldehyde