4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide
CAS No.:1623807-60-2
Molecular Formula:C₂₂H₂₅N₃O₄S₂
Molecular Weight:459.59
Hs Code.:

Synonyms:

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Chemical Property of 4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide

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Technology Process of 4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide

There total 3 articles about 4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₆N₂O₂S

: 1623807-60-2
4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

2: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

3: sodium cyanoborohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique

With copper(I) thiophene-2-carboxylate; C₃₂H₆₄O₈Rh₂; sodium cyanoborohydride; In 1,2-dichloro-ethane; toluene;
DOI:10.1002/anie.201400881

Reference yield:

: 6719-02-4
2-(1H-pyrrol-1-yl)ethanol

: 1623807-60-2
4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

2: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

3: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

4: sodium cyanoborohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique

With copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; C₃₂H₆₄O₈Rh₂; sodium cyanoborohydride; triphenylphosphine; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1002/anie.201400881

Reference yield:

: 1623807-48-6
N-(2-(1H-pyrrol-1-yl)ethyl)-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide

: 1623807-60-2
4-methyl-N-((3-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

2: sodium cyanoborohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique

With C₃₂H₆₄O₈Rh₂; sodium cyanoborohydride; In 1,2-dichloro-ethane;
DOI:10.1002/anie.201400881