2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene

Base Information

• Chemical Name: 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene
• CAS No.: 99474-19-8
• Molecular Formula: C₁₁H₁₃ClN₂O₃
• Molecular Weight: 256.689
• Mol file: 99474-19-8.mol

Synonyms:

Chemical Property of 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene

There total 3 articles about 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-nitro-4-chloro-5-methoxymethylbenzene (62492-45-9) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene (99474-19-8)

Guidance literature:

In N,N-dimethyl-formamide; for 48h; Heating;

Reference yield:

2-chloro-5-methylphenol (615-74-7) → 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene (99474-19-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaNO₂, H₂SO₄, 2.) HNO₃ / 1.) acetic acid

2: 80 percent / K₂CO₃ / ethanol

3: 80 percent / dimethylformamide / 48 h / Heating

With sulfuric acid; nitric acid; potassium carbonate; sodium nitrite; In ethanol; N,N-dimethyl-formamide;

Reference yield:

2-chloro-5-methyl-4-nitro-phenol (40130-97-0) → 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene (99474-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / K₂CO₃ / ethanol

2: 80 percent / dimethylformamide / 48 h / Heating

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

2-nitro-4-chloro-5-methoxymethylbenzene

N,N-dimethyl-formamide dimethyl acetal

2-chloro-5-methylphenol

2-chloro-5-methyl-4-nitro-phenol

Downstream raw materials:

6-chloro-5-methoxy-1H-indole

(6-chloro-5-methoxy-indol-3-yl)-acetonitrile

Refernces