(24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂

Base Information

Chemical Name:(24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂
CAS No.:131378-70-6
Molecular Formula:C₂₈H₄₆O₃
Molecular Weight:430.671
Hs Code.:

(24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D<sub>2</sub>

Synonyms:

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Chemical Property of (24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂

Chemical Property:

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Technology Process of (24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂

There total 12 articles about (24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125315-53-9
22-Oxo-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-6-cholene-1α,3β-diyl diacetate

: 131378-70-6
(24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂

Guidance literature:: Multi-step reaction with 11 steps

1: 950 g / NaBH₄ / methanol / 0.17 h / Ambient temperature

2: pyridine / 4 h / Ambient temperature

3: 1) NaI / 1) DMF, 30 min, 80 deg C, 2) 30 min, 80 deg C

4: 79 percent / KOH / methanol / 0.5 h / Heating

5: 90 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

6: 1) BuLi, HMPA / 1) THF, -78 deg C to -20 deg C, 20 min, 2) THF, -20 deg C, 1.5h

7: 53 percent / sodium amalgam (5percent), Na₂HPO₄ / methanol / 16 h / Ambient temperature

8: 83 percent / p-TsOH*H₂O, 95percent EtOH / 4 h / 80 °C

9: 86 percent / LiAlH₄ / tetrahydrofuran / Heating

10: 25 percent / diethyl ether; tetrahydrofuran / 0.05 h / Irradiation

11: ethanol / 1 h / Heating

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; ethanol; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1246/bcsj.63.2233

Reference yield:

: 125315-55-1
22-hydroxy-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinorchol-6-ene-1α,3β-diol 1,3-diacetate

: 131378-70-6
(24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine / 4 h / Ambient temperature

2: 1) NaI / 1) DMF, 30 min, 80 deg C, 2) 30 min, 80 deg C

3: 79 percent / KOH / methanol / 0.5 h / Heating

4: 90 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

5: 1) BuLi, HMPA / 1) THF, -78 deg C to -20 deg C, 20 min, 2) THF, -20 deg C, 1.5h

6: 53 percent / sodium amalgam (5percent), Na₂HPO₄ / methanol / 16 h / Ambient temperature

7: 83 percent / p-TsOH*H₂O, 95percent EtOH / 4 h / 80 °C

8: 86 percent / LiAlH₄ / tetrahydrofuran / Heating

9: 25 percent / diethyl ether; tetrahydrofuran / 0.05 h / Irradiation

10: ethanol / 1 h / Heating

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; ethanol; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1246/bcsj.63.2233

Reference yield:

: 131249-29-1
22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-6-cholene-1α,3β-diol

: 131378-70-6
(24R)-22,23-Dihydro-1α,25-dihydroxyvitamin D₂

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

2: 1) BuLi, HMPA / 1) THF, -78 deg C to -20 deg C, 20 min, 2) THF, -20 deg C, 1.5h

3: 53 percent / sodium amalgam (5percent), Na₂HPO₄ / methanol / 16 h / Ambient temperature

4: 83 percent / p-TsOH*H₂O, 95percent EtOH / 4 h / 80 °C

5: 86 percent / LiAlH₄ / tetrahydrofuran / Heating

6: 25 percent / diethyl ether; tetrahydrofuran / 0.05 h / Irradiation

7: ethanol / 1 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; ethanol; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1246/bcsj.63.2233