15β,17β-dihydroxy-androst-4-en-3-one

Base Information

• Chemical Name: 15β,17β-dihydroxy-androst-4-en-3-one
• CAS No.: 117407-11-1
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.43
• Mol file: 117407-11-1.mol

Synonyms:

Chemical Property of 15β,17β-dihydroxy-androst-4-en-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15β,17β-dihydroxy-androst-4-en-3-one

There total 22 articles about 15β,17β-dihydroxy-androst-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

17β-(dimethylthexylsiloxy)-15β-hydroxyandrost-4-en-3-one (174815-61-3) → 15beta-Hydroxytestosterone (2226-70-2,39605-73-7,87936-17-2,117407-11-1)

Guidance literature:

With hydrogenchloride; In methanol; benzene; for 7h;

DOI:10.1016/0039-128X(95)00196-W

Reference yield: 55.0%

testosterone (58-22-0) → 15beta-Hydroxytestosterone (2226-70-2,39605-73-7,87936-17-2,117407-11-1) + 2β-hydroxytestosterone (4075-14-3,10390-14-4,39605-71-5)

Guidance literature:

With glucose dehydrogenase; D-glucose; cytochrome P_450BM3 R₄₇L/Y₅₁F/F₈₇A/H₁₇₁L/Q₃₀₇H/N₃₁₉Y mutant; β-nicotinamide adenine dinucleotide phosphate sodium salt; In methanol; aq. phosphate buffer; at 25 ℃; for 2h; pH=7.5; Enzymatic reaction;

DOI:10.1002/chem.201502020

Reference yield: 11.3%

testosterone (58-22-0) → 15beta-Hydroxytestosterone (2226-70-2,39605-73-7,87936-17-2,117407-11-1) + 6β-hydroxytestosterone (62-99-7,2944-87-8,34096-63-4,34442-08-5,145772-79-8) + 1β,17β-dihydroxyandrost-4-en-3-one (19418-63-4) + 6β-hydroxy-4-androstene-3,17-dione (63-00-3) + 6β,16β,17β-trihydroxyandrost-4-en-3-one + 6-dehydro-15β-hydroxytestosterone

Guidance literature:

With human liver cytochrome P₄₅₀ enzyme 3A₄; potassium hydroxide; phosphorous acid; In methanol; aq. phosphate buffer; dimethyl sulfoxide; at 28 ℃; for 8h; pH=7.0; Enzymatic reaction;

DOI:10.1002/adsc.202000251

upstream raw materials:

androst-4-ene-3,17-dione

17β-(dimethylthexylsiloxy)-15β-hydroxyandrost-4-en-3-one

testosterone

Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-hydroxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester