N¹⁰-propargyl-5,8-dideazaisohomofolic acid

Base Information

• Chemical Name: N¹⁰-propargyl-5,8-dideazaisohomofolic acid
• CAS No.: 133933-16-1
• Molecular Formula: C₂₅H₂₅N₅O₆
• Molecular Weight: 491.503
• Mol file: 133933-16-1.mol

Synonyms:

Chemical Property of N¹⁰-propargyl-5,8-dideazaisohomofolic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹⁰-propargyl-5,8-dideazaisohomofolic acid

There total 7 articles about N¹⁰-propargyl-5,8-dideazaisohomofolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide (58677-07-9) → N10-propargyl-5,8-dideazaisohomofolic acid (133933-16-1)

Guidance literature:

Multi-step reaction with 4 steps

1: MgO / N,N-dimethyl-acetamide / 24 h / 80 °C

2: 0.1 N aq. NaOH / acetonitrile / 18 h / Ambient temperature

3: dicyclohexylcarbodiimide (DCC), pyridine / 42 h / 25 °C

4: 0.1 N aq. NaOH / 18 h / Ambient temperature

With pyridine; sodium hydroxide; magnesium oxide; dicyclohexyl-carbodiimide; In N,N-dimethyl acetamide; acetonitrile;

DOI:10.1021/jm00113a011

Reference yield:

methyl 4-(aminomethyl)benzoate hydrochloride (6232-11-7) → N10-propargyl-5,8-dideazaisohomofolic acid (133933-16-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 17 percent / K₂CO₃ / methanol / 3 h / Heating

2: MgO / N,N-dimethyl-acetamide / 24 h / 80 °C

3: 0.1 N aq. NaOH / acetonitrile / 18 h / Ambient temperature

4: dicyclohexylcarbodiimide (DCC), pyridine / 42 h / 25 °C

5: 0.1 N aq. NaOH / 18 h / Ambient temperature

With pyridine; sodium hydroxide; magnesium oxide; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl acetamide; acetonitrile;

DOI:10.1021/jm00113a011

Reference yield:

methyl 4-((prop–2–yn–1–ylamino)methyl)benzoate (133933-33-2) → N10-propargyl-5,8-dideazaisohomofolic acid (133933-16-1)

Guidance literature:

Multi-step reaction with 4 steps

1: MgO / N,N-dimethyl-acetamide / 24 h / 80 °C

2: 0.1 N aq. NaOH / acetonitrile / 18 h / Ambient temperature

3: dicyclohexylcarbodiimide (DCC), pyridine / 42 h / 25 °C

4: 0.1 N aq. NaOH / 18 h / Ambient temperature

With pyridine; sodium hydroxide; magnesium oxide; dicyclohexyl-carbodiimide; In N,N-dimethyl acetamide; acetonitrile;

DOI:10.1021/jm00113a011

upstream raw materials:

L-glutamic acid diethyl ester

N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide

methyl 4-(aminomethyl)benzoate hydrochloride

methyl 4-((prop–2–yn–1–ylamino)methyl)benzoate