DIETHYL GLUTAMATE

Base Information

• Chemical Name: DIETHYL GLUTAMATE
• CAS No.: 16450-41-2
• Molecular Formula: C9H17NO4
• Molecular Weight: 203.238
• Hs Code.: 2922499990
• Mol file: 16450-41-2.mol

Synonyms:Glutamicacid, diethyl ester, L- (6CI,7CI,8CI);L-Glutamic acid, diethyl ester (9CI);(S)-Glutamic acid diethyl ester;Diethyl L-glutamate;Glutamate diethyl ester;L-Glutamate diethyl ester;L-Glutamic acid a,g-diethyl ester;a,g-Diethyl glutamate;

Chemical Property of DIETHYL GLUTAMATE

Chemical Property:

• Melting Point: 114-116 °C
• Boiling Point: 262 °C at 760 mmHg
• PKA: 7.12±0.35(Predicted)
• Flash Point: 86.3 °C
• PSA: 78.62000
• Density: 1.08 g/cm³
• LogP: 0.92040

Purity/Quality:

99% ^*data from raw suppliers

(S)-DIETHYL-2-AMINOPENTANEDIOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYL GLUTAMATE

There total 9 articles about DIETHYL GLUTAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

diethyl-L-glutamate hydrochloride (1118-89-4) → L-glutamic acid diethyl ester (16450-41-2)

Guidance literature:

With potassium carbonate; In water; for 0.5h;

Reference yield: 80.0%

ethanol (64-17-5) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → L-glutamic acid diethyl ester (16450-41-2)

Guidance literature:

With thionyl chloride;

DOI:10.1080/10426509908044979

Reference yield:

→ L-glutamic acid diethyl ester (16450-41-2)

Guidance literature:

upstream raw materials:

ethanol

L-glutamic acid

orthoformic acid triethyl ester

2-benzyloxycarbonylamino-pentanedioic acid diethyl ester

Downstream raw materials:

(5S)-5-[(pyrrolidin-1-yl)carbonyl]pyrrolidin-2-one

diethyl N-(2-carboxybenzoyl)-L-glutamate

N-phenylsulfanylcarbonyl-L-glutamic acid

benzyloxycarbonylglycylglutamic acid

Refernces

Metal-Ammonia Reduction: Effect of Methyl Substituents and a Question Concerning Protonation Sites in Dianions

10.1021/jo00321a012

The research primarily investigates the kinetics of the hydrolysis and aminolysis of various amino esters, such as γ-ethyl glutamate, diethyl glutamate, O-acetylserine, and ethyl pyrrolidone-5-carboxylate, using a Radiometer ITTlc pH-stat to measure the rate of proton release. The study explores how factors like temperature, ionic strength, and the presence of phosphate buffers influence these reactions. Additionally, the research delves into the effects of substituents, particularly methyl groups, on Birch reductions and other metal-ammonia processes in aromatic compounds. Key chemicals involved include γ-ethyl glutamate, diethyl glutamate, O-acetylserine, ethyl pyrrolidone-5-carboxylate, sodium hydroxide, potassium chloride, and various aromatic compounds like naphthalenes and biphenyls. The study also examines the behavior of dianions and radical anions in these reactions, questioning the sites of protonation and the stability of intermediates.