Technology Process of 1α-benzyloxycarbonyl-3β-hydroxy-2α,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-1β-carboxylic acid 1-3-lactone
There total 6 articles about 1α-benzyloxycarbonyl-3β-hydroxy-2α,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-1β-carboxylic acid 1-3-lactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82 percent / Li, liquid NH3 / tetrahydrofuran / -60 - -50 °C
2: 76 percent / p-TsOH / 1,2-dichloro-ethane / 12 h / Heating
3: 1.) LDA / 1.) THF, hexane, -50 deg C -> -15 deg C, 2.) -50 deg C -> room temperature
4: 1.) formic acid, H2O2, 2.) Amberlyst 15 / 1.) room temperature, overnight, 2.) MeOH
5: CaSO4, AgO
With
silver(II) oxide; calcium sulfate; formic acid; Amberlyst 15; ammonia; dihydrogen peroxide; lithium; toluene-4-sulfonic acid; lithium diisopropyl amide;
In
tetrahydrofuran; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / NaOH, H2O2 / H2O / 100 °C
2: 82 percent / Li, liquid NH3 / tetrahydrofuran / -60 - -50 °C
3: 76 percent / p-TsOH / 1,2-dichloro-ethane / 12 h / Heating
4: 1.) LDA / 1.) THF, hexane, -50 deg C -> -15 deg C, 2.) -50 deg C -> room temperature
5: 1.) formic acid, H2O2, 2.) Amberlyst 15 / 1.) room temperature, overnight, 2.) MeOH
6: CaSO4, AgO
With
silver(II) oxide; calcium sulfate; sodium hydroxide; formic acid; Amberlyst 15; ammonia; dihydrogen peroxide; lithium; toluene-4-sulfonic acid; lithium diisopropyl amide;
In
tetrahydrofuran; water; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 76 percent / p-TsOH / 1,2-dichloro-ethane / 12 h / Heating
2: 1.) LDA / 1.) THF, hexane, -50 deg C -> -15 deg C, 2.) -50 deg C -> room temperature
3: 1.) formic acid, H2O2, 2.) Amberlyst 15 / 1.) room temperature, overnight, 2.) MeOH
4: CaSO4, AgO
With
silver(II) oxide; calcium sulfate; formic acid; Amberlyst 15; dihydrogen peroxide; toluene-4-sulfonic acid; lithium diisopropyl amide;
In
1,2-dichloro-ethane;
