(-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole

Base Information

Chemical Name:(-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole
CAS No.:173427-52-6
Molecular Formula:C₂₅H₂₇NO₄
Molecular Weight:405.494
Hs Code.:

Synonyms:

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Chemical Property of (-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole

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Technology Process of (-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole

There total 7 articles about (-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69008-03-3
2-bromo-5-hydroxy-[1,4]naphthoquinone

: 173427-52-6
(-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / silver oxide / CH₂Cl₂ / 43 h / Ambient temperature

2: sodium dithionite / diethyl ether; H₂O / 0.33 h

3: potassium carbonate / acetone / 24 h / Heating

4: 90 percent / dimethylformamide / 23 h / Heating

5: 87 percent / potassium hydroxide / 2-methyl-propan-2-ol / 3 h / Heating

6: 1.) triethyloxonium tetrafluoroborate / 1.) dichloroethane, 0 deg C, 2.) dichloroethane, reflux, 11 h

With potassium hydroxide; sodium dithionite; triethyloxonium fluoroborate; potassium carbonate; silver(l) oxide; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1071/CH9952013

Reference yield:

: 100-39-0
benzyl bromide

: 173427-52-6
(-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / silver oxide / CH₂Cl₂ / 43 h / Ambient temperature

2: sodium dithionite / diethyl ether; H₂O / 0.33 h

3: potassium carbonate / acetone / 24 h / Heating

4: 90 percent / dimethylformamide / 23 h / Heating

5: 87 percent / potassium hydroxide / 2-methyl-propan-2-ol / 3 h / Heating

6: 1.) triethyloxonium tetrafluoroborate / 1.) dichloroethane, 0 deg C, 2.) dichloroethane, reflux, 11 h

With potassium hydroxide; sodium dithionite; triethyloxonium fluoroborate; potassium carbonate; silver(l) oxide; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1071/CH9952013

Reference yield:

: 119650-42-9
5-benzyloxy-2-bromo-1,4-dimethoxynaphthalene

: 173427-52-6
(-)-(4S)-2-(5'-benzyloxy-1',4'-dimethoxy-2'-naphthyl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / dimethylformamide / 23 h / Heating

2: 87 percent / potassium hydroxide / 2-methyl-propan-2-ol / 3 h / Heating

3: 1.) triethyloxonium tetrafluoroborate / 1.) dichloroethane, 0 deg C, 2.) dichloroethane, reflux, 11 h

With potassium hydroxide; triethyloxonium fluoroborate; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1071/CH9952013