3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Base Information

Chemical Name:3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
CAS No.:191993-64-3
Molecular Formula:C₁₅H₁₁N₅O₂S
Molecular Weight:325.351
Hs Code.:

Synonyms:

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Chemical Property of 3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

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Technology Process of 3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

There total 4 articles about 3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 163137-34-6
N-phenyl-4-aminopyridine-3-sulphonamide

: 191993-64-3
3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Guidance literature:: In 1,4-dioxane; N,N-dimethyl-formamide; for 1.5h; Heating; stirring under reflux; solvent removing;ppt. dissolving in aq. NaOH; cooling on ice; ppt. collecting, wasshing with water;

Reference yield:

: 33263-44-4
4-chloro-pyridine-3-sulfonyl chloride

: 191993-64-3
3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / triethylamine / dioxane / 1 h / 20 °C / sulfonyl chloride adding dropwise to aniline and Et₃N; stirring; evapg.; dissolving in aq. NaOH; ppt. treating with 1 M HCl

2: 86 percent / aq. NH₃ / 12 h / 150 °C / Heating; heating in autoclave; concg.; ppt. collecting, wasing with water and drying

3: 54 percent / dimethylformamide; dioxane / 1.5 h / Heating; stirring under reflux; solvent removing;ppt. dissolving in aq. NaOH; cooling on ice; ppt. collecting, wasshing with water

With triethylamine; In 1,4-dioxane; ammonium hydroxide; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Cyclization;

Reference yield:

: 62-53-3
aniline

: 191993-64-3
3-(1H-imidazol-1-yl)-2-phenyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / triethylamine / dioxane / 1 h / 20 °C / sulfonyl chloride adding dropwise to aniline and Et₃N; stirring; evapg.; dissolving in aq. NaOH; ppt. treating with 1 M HCl

2: 86 percent / aq. NH₃ / 12 h / 150 °C / Heating; heating in autoclave; concg.; ppt. collecting, wasing with water and drying

3: 54 percent / dimethylformamide; dioxane / 1.5 h / Heating; stirring under reflux; solvent removing;ppt. dissolving in aq. NaOH; cooling on ice; ppt. collecting, wasshing with water

With triethylamine; In 1,4-dioxane; ammonium hydroxide; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Cyclization;