Technology Process of (3S,4R)-N-benzyl-3-hydroxymethyl-4-(1',3'-dihydroxyisopropoxy)-azetidinone
There total 7 articles about (3S,4R)-N-benzyl-3-hydroxymethyl-4-(1',3'-dihydroxyisopropoxy)-azetidinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridine
2: 2.) ammonia / 1.) nitromethane, room temp., 4 d; 2.) nitromethane, -30 deg C
3: 68 percent / K2CO3, tetrabutylammonium bromide / benzene / 2 h / Heating
4: 80 percent / H2 / Pd/C / methanol / 4 h / 760 Torr / Ambient temperature
5: ammonium sulfate, sodium metaperiodate / methanol; H2O / 0.08 h / -5 °C
6: sodium borohydride / methanol; H2O
With
sodium tetrahydroborate; ammonium sulfate; sodium periodate; tetrabutylammomium bromide; ammonia; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
pyridine; methanol; water; benzene;
DOI:10.1016/S0040-4020(01)89183-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / K2CO3, tetrabutylammonium bromide / benzene / 2 h / Heating
2: 80 percent / H2 / Pd/C / methanol / 4 h / 760 Torr / Ambient temperature
3: ammonium sulfate, sodium metaperiodate / methanol; H2O / 0.08 h / -5 °C
4: sodium borohydride / methanol; H2O
With
sodium tetrahydroborate; ammonium sulfate; sodium periodate; tetrabutylammomium bromide; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
methanol; water; benzene;
DOI:10.1016/S0040-4020(01)89183-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / K2CO3, tetrabutylammonium bromide / benzene / 2 h / Heating
2: 80 percent / H2 / Pd/C / methanol / 4 h / 760 Torr / Ambient temperature
3: ammonium sulfate, sodium metaperiodate / methanol; H2O / 0.08 h / -5 °C
4: sodium borohydride / methanol; H2O
With
sodium tetrahydroborate; ammonium sulfate; sodium periodate; tetrabutylammomium bromide; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
methanol; water; benzene;
DOI:10.1016/S0040-4020(01)89183-3