Technology Process of 4-((1S,2R,3S,6R)-3-Isopropyl-2-methoxymethoxy-6-methyl-cyclohexyl)-butan-2-one
There total 14 articles about 4-((1S,2R,3S,6R)-3-Isopropyl-2-methoxymethoxy-6-methyl-cyclohexyl)-butan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 14 steps
2: TsN3, Et3N
3: Rh2(OAc)4
4: 1.) MeONa, 2.) p-TsOH / 1.) MeOH, 2.) CH2Cl2
5: 90 percent / LiAlH4 / diethyl ether
6: 91 percent / imidazole / dimethylformamide
7: 83 percent / Dess-Martin periodinane / CH2Cl2
8: 89 percent / L-Selectride / tetrahydrofuran
9: 74 percent / Et3N / CH2Cl2
10: 94 percent / TBAF / tetrahydrofuran
11: (COCl)2, DMSO, Et3N
12: BuLi / tetrahydrofuran
13: KOH / methanol
14: 1.) DPPA, Et3N, 2.) aq. HCl / 1.) CH2Cl2, 2.) methanol, room temp.
With
1H-imidazole; hydrogenchloride; dirhodium tetraacetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; 4-toluenesulfonyl azide; oxalyl dichloride; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; sodium methylate; L-Selectride; Dess-Martin periodane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.739
- Guidance literature:
-
Multi-step reaction with 12 steps
1: Rh2(OAc)4
2: 1.) MeONa, 2.) p-TsOH / 1.) MeOH, 2.) CH2Cl2
3: 90 percent / LiAlH4 / diethyl ether
4: 91 percent / imidazole / dimethylformamide
5: 83 percent / Dess-Martin periodinane / CH2Cl2
6: 89 percent / L-Selectride / tetrahydrofuran
7: 74 percent / Et3N / CH2Cl2
8: 94 percent / TBAF / tetrahydrofuran
9: (COCl)2, DMSO, Et3N
10: BuLi / tetrahydrofuran
11: KOH / methanol
12: 1.) DPPA, Et3N, 2.) aq. HCl / 1.) CH2Cl2, 2.) methanol, room temp.
With
1H-imidazole; hydrogenchloride; dirhodium tetraacetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; sodium methylate; L-Selectride; Dess-Martin periodane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.739
- Guidance literature:
-
Multi-step reaction with 13 steps
1: TsN3, Et3N
2: Rh2(OAc)4
3: 1.) MeONa, 2.) p-TsOH / 1.) MeOH, 2.) CH2Cl2
4: 90 percent / LiAlH4 / diethyl ether
5: 91 percent / imidazole / dimethylformamide
6: 83 percent / Dess-Martin periodinane / CH2Cl2
7: 89 percent / L-Selectride / tetrahydrofuran
8: 74 percent / Et3N / CH2Cl2
9: 94 percent / TBAF / tetrahydrofuran
10: (COCl)2, DMSO, Et3N
11: BuLi / tetrahydrofuran
12: KOH / methanol
13: 1.) DPPA, Et3N, 2.) aq. HCl / 1.) CH2Cl2, 2.) methanol, room temp.
With
1H-imidazole; hydrogenchloride; dirhodium tetraacetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; 4-toluenesulfonyl azide; oxalyl dichloride; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; sodium methylate; L-Selectride; Dess-Martin periodane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.739
