Technology Process of ((6E,8E,10E)-(2R,4R)-5,12-Bis-benzyloxy-2,4,10-trimethyl-dodeca-6,8,10-trienyloxy)-tert-butyl-dimethyl-silane
There total 9 articles about ((6E,8E,10E)-(2R,4R)-5,12-Bis-benzyloxy-2,4,10-trimethyl-dodeca-6,8,10-trienyloxy)-tert-butyl-dimethyl-silane which
guide to synthetic route it.
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synthetic route:
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101376-80-1,101469-61-8,125590-91-2
((6E,8E,10E)-(2R,4R)-5,12-Bis-benzyloxy-2,4,10-trimethyl-dodeca-6,8,10-trienyloxy)-tert-butyl-dimethyl-silane
- Guidance literature:
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Multi-step reaction with 7 steps
1: (COCl)2, Me2SO, Et3N / CH2Cl2
2: -78 °C
3: Bu4NF / tetrahydrofuran / 0 - 23 °C
4: n-BuLi / tetrahydrofuran / -78 °C
5: tetrahydrofuran / -40 °C
6: red-Al / diethyl ether / 0 - 23 °C
7: n-BuLi, HMPA / tetrahydrofuran
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00359a060
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101376-80-1,101469-61-8,125590-91-2
((6E,8E,10E)-(2R,4R)-5,12-Bis-benzyloxy-2,4,10-trimethyl-dodeca-6,8,10-trienyloxy)-tert-butyl-dimethyl-silane
- Guidance literature:
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Multi-step reaction with 9 steps
1: CH2Cl2
2: DIBAH / diethyl ether / -78 °C
3: (COCl)2, Me2SO, Et3N / CH2Cl2
4: -78 °C
5: Bu4NF / tetrahydrofuran / 0 - 23 °C
6: n-BuLi / tetrahydrofuran / -78 °C
7: tetrahydrofuran / -40 °C
8: red-Al / diethyl ether / 0 - 23 °C
9: n-BuLi, HMPA / tetrahydrofuran
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00359a060
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101376-80-1,101469-61-8,125590-91-2
((6E,8E,10E)-(2R,4R)-5,12-Bis-benzyloxy-2,4,10-trimethyl-dodeca-6,8,10-trienyloxy)-tert-butyl-dimethyl-silane
- Guidance literature:
-
Multi-step reaction with 6 steps
1: -78 °C
2: Bu4NF / tetrahydrofuran / 0 - 23 °C
3: n-BuLi / tetrahydrofuran / -78 °C
4: tetrahydrofuran / -40 °C
5: red-Al / diethyl ether / 0 - 23 °C
6: n-BuLi, HMPA / tetrahydrofuran
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; tetrabutyl ammonium fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00359a060
