(S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid

Base Information

Chemical Name:(S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid
CAS No.:1149388-45-3
Molecular Formula:C₁₃H₁₈N₂O₃
Molecular Weight:250.298
Hs Code.:

Synonyms:

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Chemical Property of (S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid

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Technology Process of (S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid

There total 4 articles about (S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398112-08-7
C₁₄H₂₀N₂O₃

: 1149388-45-3
(S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 45 ℃;
DOI:10.1016/j.bmcl.2012.07.052

Reference yield:

: 1149388-41-9
methyl 5-amino-4-cyano-2-methylbenzoate

: 1149388-45-3
(S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; diiodomethane; isopentyl nitrite / tetrahydrofuran / 85 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 95 °C

3: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide

4: sodium hydroxide / methanol; water / 45 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; diiodomethane; dihydrogen peroxide; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; 1: Sandmeyer iodination;
DOI:10.1016/j.bmcl.2012.07.052

Reference yield:

: 103261-67-2
4-cyano-2-methylbenzoic acid methyl ester

: 1149388-45-3
(S)-5-(sec-butylamino)-4-(aminocarbonyl)-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; nitric acid / -10 - 0 °C

2: iron; acetic acid / 45 °C

3: copper(l) iodide; diiodomethane; isopentyl nitrite / tetrahydrofuran / 85 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 95 °C

5: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide

6: sodium hydroxide / methanol; water / 45 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; diiodomethane; sulfuric acid; dihydrogen peroxide; nitric acid; iron; potassium carbonate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; 3: Sandmeyer iodination;
DOI:10.1016/j.bmcl.2012.07.052