methyl 4-cyano-2-methylbenzoate

Base Information

• Chemical Name: methyl 4-cyano-2-methylbenzoate
• CAS No.: 103261-67-2
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Hs Code.: 2926909090
• Mol file: 103261-67-2.mol

Synonyms:methyl 4-cyano-2-methylbenzoate

Chemical Property of methyl 4-cyano-2-methylbenzoate

Chemical Property:

• Boiling Point: 302.7±30.0 °C(Predicted)
• PSA: 50.09000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 1.65328
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥99.0% ^*data from raw suppliers

Methyl4-Cyano-2-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-cyano-2-methylbenzoate?is a carboxylate derivative and can be used as an intermediate in organic synthesis.

Technology Process of methyl 4-cyano-2-methylbenzoate

There total 10 articles about methyl 4-cyano-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-bromo-2-methyl-benzoic acid methyl ester (99548-55-7) + dicyanozinc (557-21-1) → 4-cyano-2-methylbenzoic acid methyl ester (103261-67-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield: 89.0%

zinc(II) cyanide (557-21-1) + 4-bromo-2-methyl-benzoic acid methyl ester (99548-55-7) → 4-cyano-2-methylbenzoic acid methyl ester (103261-67-2)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield: 89.0%

zinc(II) cyanide (557-21-1) + 4-bromo-2-methylbenzoic acid (68837-59-2) → 4-cyano-2-methylbenzoic acid methyl ester (103261-67-2)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

upstream raw materials:

methanol

4-Cyano-2-methylbenzoic acid

4-bromo-2-methyl-benzoic acid methyl ester

copper(I) cyanide

Downstream raw materials:

4-Cyano-2-methylbenzoic acid

C₁₅H₂₀N₂O₂

C₁₃H₁₆N₂O₂

C₁₃H₁₆N₂O₂

Refernces

• 1、 -. "Method for preparing 2-methyl-4-formaldoxime methyl benzoate". Paragraph 0015; 0016. . Retrieved 2017/04/03.
• 2、 -. "Novel Imidazoles for the Treatment and Prophylaxis of Respiratory Syncytial Virus Infection". Paragraph 0223; 0224. . Retrieved 2016/11/28.