Benzonitrile,4-[[(3aS,4S,9R,9aR)-1,3,3a,4,9,9a-hexahydro-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-4-yl]amino]-

Base Information

Chemical Name:Benzonitrile,4-[[(3aS,4S,9R,9aR)-1,3,3a,4,9,9a-hexahydro-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-4-yl]amino]-
CAS No.:138355-92-7
Molecular Formula:C₃₀H₃₀N₂O₇
Molecular Weight:530.577
Hs Code.:

Synonyms:Benzonitrile,4-[[1,3,3a,4,9,9a-hexahydro-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-4-yl]amino]-,[3aS-(3aa,4b,9a,9ab)]-; Naphtho[2,3-c]furan,benzonitrile deriv.

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzonitrile,4-[[(3aS,4S,9R,9aR)-1,3,3a,4,9,9a-hexahydro-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-4-yl]amino]-

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzonitrile,4-[[(3aS,4S,9R,9aR)-1,3,3a,4,9,9a-hexahydro-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-4-yl]amino]-

There total 3 articles about Benzonitrile,4-[[(3aS,4S,9R,9aR)-1,3,3a,4,9,9a-hexahydro-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-4-yl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 138355-92-7
6,7-O,O-demethylene-6,7-O,O-dimethyl-4β-(4-cyanoanilino)-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / boron trichloride / CH₂Cl₂ / 1 h / -70 - -65 °C

2: 94 percent / diethyl ether; methanol / 3 h / Ambient temperature

3: 1.) HBr, 2.) barium carbonate / 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight

With hydrogen bromide; boron trichloride; barium carbonate; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00083a010

Reference yield:

: 138456-91-4
6,7-O,O-demethylene-4'-O-demethylepipodophyllotoxin

: 138355-92-7
6,7-O,O-demethylene-6,7-O,O-dimethyl-4β-(4-cyanoanilino)-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / diethyl ether; methanol / 3 h / Ambient temperature

2: 1.) HBr, 2.) barium carbonate / 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight

With hydrogen bromide; barium carbonate; In methanol; diethyl ether;
DOI:10.1021/jm00083a010

Reference yield:

: 1178-09-2
(3aR,4S,9R,9aR)-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one

: 873-74-5
4-Aminobenzonitrile

: 138355-96-1
6,7-O,O-demethylene-6,7-O,O-dimethyl-4'-O-demethyl-4β-(4-cyanoanilino)-4-desoxypodophyllotoxin

: 138355-92-7
6,7-O,O-demethylene-6,7-O,O-dimethyl-4β-(4-cyanoanilino)-4-desoxypodophyllotoxin

Guidance literature:: With hydrogen bromide; barium carbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight;
DOI:10.1021/jm00083a010