4-CHLORO-4'-METHYLBENZHYDROL

Base Information

• Chemical Name: 4-CHLORO-4'-METHYLBENZHYDROL
• CAS No.: 13389-74-7
• Molecular Formula: C14H13ClO
• Molecular Weight: 232.71
• Hs Code.: 2906299090
• Mol file: 13389-74-7.mol

Synonyms:4-chloro-4'-methyldiphenylmethanol;(4-Methyl-phenaethyl)-hydrazin;HYDRAZINE,(p-METHYLPHENETHYL);4-Methylphenelzine;(+/-)-4-chlorophenyl-4'-methylphenylmethanol;p-Methylphenelzine;(4-methylphenyl)(4'-chlorophenyl)methanol;(p-Methylphenethyl)hydrazine;2-(p-Tolyl)ethylhydrazin;4-chloro-4'methylbenzhydrol;(4-methyl-phenethyl)-hydrazine;

Chemical Property of 4-CHLORO-4'-METHYLBENZHYDROL

Chemical Property:

• PSA: 20.23000
• LogP: 3.73010

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-4''-methylbenzhydrol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-4'-METHYLBENZHYDROL

There total 11 articles about 4-CHLORO-4'-METHYLBENZHYDROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methylphenylboronic acid (5720-05-8) + 4-chlorobenzaldehyde (104-88-1) → 4-chloro-4'methylbenzhydrol (13389-74-7)

Guidance literature:

With hexakis{[3-(2,4,6-trimethylphenyl)imidazolio]methyl}benzene hexabromide; potassium tert-butylate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In 1,4-dioxane; water; at 80 ℃; for 16h;

DOI:10.1016/j.jorganchem.2005.09.022

Reference yield: 74.0%

trans-carbonyl(4-tolyl)bis(triphenylphosphine)rhodium(I) + 4-chlorobenzaldehyde (104-88-1) → carbonyl(hydroxy)bis(triphenylphosphine)rhodium(I) (32354-36-2,24444-24-4) + 4-chloro-4'methylbenzhydrol (13389-74-7)

Guidance literature:

With Cp₂Fe; In tetrahydrofuran-d8; water-d2; under N2, standard Schlenk techniques; in NMR tube; THF-d8 added to mixt. of Rh complex and Cp2Fe (small amt.); aldehyde (20 equiv.) added; degassed D2O added; stirred at room temp. for 24 h; not isolated; monitored by (1)H NMR spectra;

DOI:10.1021/ja017401e

Reference yield: 65.0%

4-chlorobenzaldehyde (104-88-1) + para-methylphenylmagnesium bromide (4294-57-9) → 4-chloro-4'methylbenzhydrol (13389-74-7)

Guidance literature:

In diethyl ether; at 22 ℃; for 4h;

DOI:10.1016/0957-4166(94)00374-K

upstream raw materials:

4'-methyl-4-chlorobenzophenone

sodium isopropylate

isopropyl alcohol

4-chlorobenzaldehyde

Downstream raw materials:

1-((4-chlorophenyl)((4-chlorophenyl)(p-tolyl)-methoxy)methyl)-4-methylbenzene

4-chloro-4'-methylbenzhydrylchloride

4'-methyl-4-chlorobenzophenone

{2-[(4-Chloro-phenyl)-p-tolyl-methoxy]-ethyl}-dimethyl-amine

Refernces

• 1、 Ishida, Seima,Suzuki, Hiroyuki,Uchida, Seiichiro,Yamaguchi, Eiji,Itoh, Akichika. "Nickel Catalyzed Intermolecular Carbonyl Addition of Aryl Halide". supporting information. p. 7483 - 7487. Retrieved 2019/12/11.
• 2、 Wang, Hui,Zhu, Xingfei,Lu, Yangning,Li, Yue,Gao, Xiang. "Sodium bisulfite: An efficient catalyst for ether formation via dehydration of aromatic/aliphatic alcohol". experimental part. p. 1180 - 1184. Retrieved 2012/04/23.