(+)-(S)-4-chlorophenyl-4'-methylphenylmethanol

Base Information

• Chemical Name: (+)-(S)-4-chlorophenyl-4'-methylphenylmethanol
• CAS No.: 162300-69-8
• Molecular Formula: C₁₄H₁₃ClO
• Molecular Weight: 232.71
• Mol file: 162300-69-8.mol

Synonyms:(+)-(S)-4-chlorophenyl-4'-methylphenylmethanol

Chemical Property of (+)-(S)-4-chlorophenyl-4'-methylphenylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(S)-4-chlorophenyl-4'-methylphenylmethanol

There total 12 articles about (+)-(S)-4-chlorophenyl-4'-methylphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C8H10Zn (1352313-28-0) + 4-chlorobenzaldehyde (104-88-1) → (+)-(S)-4-chlorophenyl-4'-methylphenylmethanol (162300-69-8)

Guidance literature:

C₈H₁₀Zn; With diphenyl-((S)-1-((S)-1-phenylethyl)aziridin-2-yl)-methanol; In hexane; toluene; at 25 ℃; for 0.25h;

4-chlorobenzaldehyde; In hexane; toluene; at 0 ℃; for 48h; enantioselective reaction;

DOI:10.1021/jo500796w

Reference yield: 88.0%

4-chlorobenzaldehyde (104-88-1) + tri(p-tolyl)bismuth (5142-75-6) → (+)-(S)-4-chlorophenyl-4'-methylphenylmethanol (162300-69-8)

Guidance literature:

tri(p-tolyl)bismuth; With dimethyl zinc(II); In hexane; toluene; for 10h; Heating;

4-chlorobenzaldehyde; In hexane; toluene; at 0 ℃; for 16h; Further stages.;

DOI:10.1002/ejoc.200700212

Reference yield: 86.0%

4-Chlorophenylboronic acid (1679-18-1) + 4-methyl-benzaldehyde (104-87-0) → (+)-(S)-4-chlorophenyl-4'-methylphenylmethanol (162300-69-8)

Guidance literature:

4-Chlorophenylboronic acid; With diethylzinc; In toluene; at 60 ℃; for 12h; Inert atmosphere;

With 2-((S)-1-amino-2,2-dimethylpropyl)-4,6-di(tert-butyl)phenol; In toluene; at 20 ℃; Inert atmosphere;

4-methyl-benzaldehyde; optical yield given as %ee; enantioselective reaction; Further stages;

DOI:10.1016/j.tetasy.2009.01.025

upstream raw materials:

4-chloro-4'methylbenzhydrol

4-chlorobenzaldehyde

tri(p-tolyl)bismuth

4-methylphenylboronic acid

Downstream raw materials:

(R)-(4-Methylphenyl)phenylmethanol