Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate

Base Information

Chemical Name:Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate
CAS No.:250649-33-3
Molecular Formula:C₄₂H₄₆Cl₂N₃O₇PSi
Molecular Weight:834.808
Hs Code.:

Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate

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Chemical Property of Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate

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Technology Process of Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate

There total 3 articles about Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 250649-24-2
Bis(o-chlorophenyl)[1-(3'-O-tert-butyldiphenylsilyl-2',5',6'-trideoxy-Β-D-erythro-hex-5'-enofuranosyl)-4-N-isobutyrylcytosin-6'-yl]phosphonate

: 250649-33-3
Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate

Guidance literature:: With pyridine; potassium diazodicarboxylate; acetic acid;
DOI:10.1039/a906066i

Reference yield:

: 149741-59-3
Bis(o-chlorophenyl) (triphenylphosphoranylidenemethyl)phosphonate

: 250649-33-3
Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: DCC; CF₃COOH; pyridine / dimethylsulfoxide / 20 h

1.2: dimethylsulfoxide / 6 h

2.1: 75 percent / potassium azodicarboxylate; pyridine; acetic acid

With pyridine; potassium diazodicarboxylate; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dimethyl sulfoxide; 1.1: Oxidation / 1.2: Wittig reaction / 2.1: Reduction;
DOI:10.1039/a906066i

Reference yield:

: 3'-O-tert-Butyldiphenylsilyl-2'-deoxycytidine

: 250649-33-3
Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: DCC; CF₃COOH; pyridine / dimethylsulfoxide / 20 h

1.2: dimethylsulfoxide / 6 h

2.1: 75 percent / potassium azodicarboxylate; pyridine; acetic acid

With pyridine; potassium diazodicarboxylate; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dimethyl sulfoxide; 1.1: Oxidation / 1.2: Wittig reaction / 2.1: Reduction;
DOI:10.1039/a906066i