149741-59-3

Upstream product

• 105972-87-0 di(2-chlorophenyl) chloromethylphosphonate 
• 603-35-0 triphenylphosphine 
• 95-57-8 2-monochlorophenol 

Downstream Products

• 250649-24-2 Bis(o-chlorophenyl)[1-(3'-O-tert-butyldiphenylsilyl-2',5',6'-trideoxy-Β-D-erythro-hex-5'-enofuranosyl)-4-N-isobutyrylcytosin-6'-yl]phosphonate 
• 250649-33-3 Bis(o-chlorophenyl)[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytosin-6`-yl]phosphonate 
• 250649-66-2 4-Methoxy-1-oxido-2-picolyl o-chlorophenyl[1-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-4-N-isobutyrylcytidin-6`-yl]phosphonate 
• 182810-28-2 C₄₈H₄₈ClN₄O₁₃P 
• 182810-26-0 C₂₇H₃₀ClN₄O₁₁P 
• 149741-60-6 {(E)-2-[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-vinyl}-phosphonic acid bis-(2-chloro-phenyl) ester 

Relevant academic research and scientific papers

Synthesis and some conformational features of the 5'-deoxy-5'-methylphosphonate linked dimer, 5'-deoxy-5'-C-(phosphonomethyl)thymidin-3'-yl (thymidin-5'-yl)methylphosphonate [p(CH2)Tp(CH2)T]

Efficient synthesis of the 5'-deoxy-5'-methylphosphonate linked thymidine dimer 11 [p(CH2)Tp(CH2)T] was developed via the 5'-deoxy-5'-C-(phosphonomethyl)-3'-silylated thymidine derivative 4 as a key intermediate. Conformational analy

Synthesis and preliminary biochemical studies with 5'-deoxy-5'-methylidyne phosphonate linked thymidine oligonucleotides

Thymidine deoxyoligonucleotides having a 5'-deoxy-5'-methylidyne phosphonate internucleotide linkage were synthesized. Relative to natural DNA, these oligomers were nuclease resistant and formed duplexes with reduced stability.

Synthesis of 5'-deoxy-5'-methylphosphonate linked thymidine oligonucleotides

A 5'-deoxy-5'-methylphosphonate linked thymidine dinucleotide was synthesized and its 3'-phosphoramidite used to synthesize oligonucleotides.