({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

Base Information

Chemical Name:({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium
CAS No.:1531593-81-3
Molecular Formula:C₆H₁₅N*C₃₃H₃₆F₂N₈O₇S₂
Molecular Weight:860.019
Hs Code.:

({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

Synonyms:

Suppliers and Price of ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

There total 7 articles about ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1531593-78-8
ethyl 4-[2-fluoro-4-({[4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl}amino)phenyl]piperazine-1-carboxylate

: 121-44-8
triethylamine

: 957-68-6
7-Aminocephalosporanic acid

: 1531593-81-3
({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 1531593-74-4
ethyl 4-{2-fluoro-4-[(2-hydrazinyl-2-oxoethyl)amino]phenyl}piperazine-1-carboxylate

: 1531593-81-3
({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 10 h / Reflux

2: sodium hydroxide / water / 3 h / Reflux

3: tetrahydrofuran / 4 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 120-43-4
4-ethoxycarbonylpiperazine

: 1531593-81-3
({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium

Guidance literature:: Multi-step reaction with 7 steps

1: 6 h / Reflux

2: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 7 h / Reflux

3: triethylamine / tetrahydrofuran / 14 h / 0 - 20 °C

4: hydrazine hydrate / ethanol / 14 h / Reflux

5: ethanol / 10 h / Reflux

6: sodium hydroxide / water / 3 h / Reflux

7: tetrahydrofuran / 4 h / 20 °C

With palladium on activated charcoal; hydrazine hydrate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1007/s00044-013-0898-4