Technology Process of N,N-Diisopropyl-6-methyl-4-(2,3,5-trimethoxy-benzoyl)-nicotinamide
There total 5 articles about N,N-Diisopropyl-6-methyl-4-(2,3,5-trimethoxy-benzoyl)-nicotinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi, 2,2,6,6-tetramethylpiperidine / 1.) hexane/DME, -78 deg C, 1 h; 2.) DME, 15 min
2: 58 percent / 1,2-dimethoxy-ethane / 1.) 30 min, -78 deg C; 2.) 8 h, room temp.
3: 56 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature
4: 60 percent / benzenesulfonyl chloride / acetonitrile / 4 h
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid;
In
1,2-dimethoxyethane; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)87704-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / NBS / CCl4 / 2 h / Heating
2: 77 percent / K2CO3 / 4 h / Heating
3: 58 percent / 1,2-dimethoxy-ethane / 1.) 30 min, -78 deg C; 2.) 8 h, room temp.
4: 56 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature
5: 60 percent / benzenesulfonyl chloride / acetonitrile / 4 h
With
N-Bromosuccinimide; potassium carbonate; benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrachloromethane; 1,2-dimethoxyethane; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)87704-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 58 percent / 1,2-dimethoxy-ethane / 1.) 30 min, -78 deg C; 2.) 8 h, room temp.
2: 56 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature
3: 60 percent / benzenesulfonyl chloride / acetonitrile / 4 h
With
benzenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid;
In
1,2-dimethoxyethane; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)87704-8
