bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane

Base Information

• Chemical Name: bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane
• CAS No.: 1056902-90-9
• Molecular Formula: C₂₀H₂₈O₄Si
• Molecular Weight: 360.525
• Mol file: 1056902-90-9.mol

Synonyms:

Chemical Property of bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane

There total 1 articles about bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethoxy-1-(4-bromophenyl)methane (24856-58-4) + dimethylsilicon dichloride (75-78-5,30107-43-8) → bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane (1056902-90-9)

Guidance literature:

1,1-dimethoxy-1-(4-bromophenyl)methane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

dimethylsilicon dichloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 13h;

DOI:10.1016/S0957-4166(01)00445-1

Reference yield:

bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane (1056902-90-9) → (1R)-3-methylene-1,5-diphenylpentanol

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrochloric acid / tetrahydrofuran; hexane; H₂O

1.2: 2.18 g / acetic acid / H₂O / 3 h / 20 °C

2.1: 90 percent / NaH / tetrahydrofuran / 2 h / 20 °C

3.1: 98 percent / H₂ / 10 percent Pd/C / ethyl acetate / 12 h

4.1: Mg / diethyl ether

4.2: CeCl₃ / tetrahydrofuran; diethyl ether / 1 h / -78 °C

4.3: tetrahydrofuran; diethyl ether / 14 h / -78 - 20 °C

5.1: acetic acid; silica gel / hexane / 0.5 h

6.1: (2R,3R)-2-O-(2,6-diisopropoxybenzoyl)tartaric acid; 3,5-bis(trifluoromethyl)phenylboronic acid / various solvent(s) / 12 h / -78 °C

6.2: Bu₄NF / tetrahydrofuran / 24 h / 60 °C

With hydrogenchloride; (2R,3R)-2-O-(2,6-diisopropoxybenzoyl)tartaric acid; hydrogen; silica gel; sodium hydride; magnesium; acetic acid; 3,5-bis-trifluromethylphenylboronic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; water; ethyl acetate; 2.1: Horner-Emmons reaction;

DOI:10.1016/S0957-4166(01)00445-1

Reference yield:

bis-(4-dimethoxymethyl-phenyl)-dimethyl-silane (1056902-90-9) → (1S)-3-methylene-1,5-diphenylpentanol

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrochloric acid / tetrahydrofuran; hexane; H₂O

1.2: 2.18 g / acetic acid / H₂O / 3 h / 20 °C

2.1: 90 percent / NaH / tetrahydrofuran / 2 h / 20 °C

3.1: 98 percent / H₂ / 10 percent Pd/C / ethyl acetate / 12 h

4.1: Mg / diethyl ether

4.2: CeCl₃ / tetrahydrofuran; diethyl ether / 1 h / -78 °C

4.3: tetrahydrofuran; diethyl ether / 14 h / -78 - 20 °C

5.1: acetic acid; silica gel / hexane / 0.5 h

6.1: (2R,3R)-2-O-(2,6-diisopropoxybenzoyl)tartaric acid; 3,5-bis(trifluoromethyl)phenylboronic acid / various solvent(s) / 12 h / -78 °C

6.2: Bu₄NF / tetrahydrofuran / 24 h / 60 °C

With hydrogenchloride; (2R,3R)-2-O-(2,6-diisopropoxybenzoyl)tartaric acid; hydrogen; silica gel; sodium hydride; magnesium; acetic acid; 3,5-bis-trifluromethylphenylboronic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; water; ethyl acetate; 2.1: Horner-Emmons reaction;

DOI:10.1016/S0957-4166(01)00445-1

upstream raw materials:

1,1-dimethoxy-1-(4-bromophenyl)methane

dimethylsilicon dichloride

Downstream raw materials:

di(4-formylphenyl)dimethylsilane

3-(4-{[4-(2-ethoxycarbonyl-ethyl)-phenyl]-dimethyl-silanyl}-phenyl)-propionic acid ethyl ester

C₃₀H₄₈Si₃