Thiol-PEG2-acid

Base Information

Chemical Name:Thiol-PEG2-acid
CAS No.:1379649-73-6
Molecular Formula:C₇H₁₄O₄S
Molecular Weight:194.252
Hs Code.:2930909899
Mol file:1379649-73-6.mol

Synonyms:

Suppliers and Price of Thiol-PEG2-acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Thiol-PEG2-acid
10mg
$ 100.00

purepeg
HS-PEG2-CH2CH2COOH min.95%
250 mg
$ 193.00

BroadPharm
Thiol-PEG2-acid 95%
1 G
$ 320.00

Apolloscientific
Thiol-PEG2-acid
500mg
$ 457.00

Apolloscientific
Thiol-PEG2-acid
250mg
$ 363.00

Absolute Chiral
3-(2-(2-mercaptoethoxy)ethoxy)propanoicacid techgrade
100 mg
$ 188.00

Total 9 raw suppliers

Chemical Property of Thiol-PEG2-acid

Chemical Property:

Boiling Point:329.0±32.0 °C(Predicted)
PKA:4.27±0.10(Predicted)
Density:1.173±0.06 g/cm3(Predicted)
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:Chloroform (Sparingly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Thiol-PEG2-acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Thiol-PEG2-acid is a PEG linker containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of Thiol-PEG2-acid

There total 4 articles about Thiol-PEG2-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1379649-82-7
ethyl 3-(2-(2-(acetylthio)ethoxy)ethoxy)propanoate

: 1379649-73-6
3-(2-(2-mercaptoethoxy)ethoxy)propanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2.6h; Inert atmosphere;
DOI:10.1002/chem.201103422

Reference yield:

: 1379649-80-5
ethyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate

: 1379649-73-6
3-(2-(2-mercaptoethoxy)ethoxy)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 4 h / 70 °C / Inert atmosphere

3: sodium hydroxide / tetrahydrofuran; water / 2.6 h / 20 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201103422

Reference yield:

: 1379649-81-6
ethyl 3-(2-(2-(tosyloxy)ethoxy)ethoxy)propanoate

: 1379649-73-6
3-(2-(2-mercaptoethoxy)ethoxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 4 h / 70 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; water / 2.6 h / 20 °C / Inert atmosphere

With sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201103422