5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil

Base Information

Chemical Name:5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil
CAS No.:474644-27-4
Molecular Formula:C₂₇H₃₅N₄O₁₀P
Molecular Weight:606.569
Hs Code.:

Synonyms:

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Chemical Property of 5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil

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Technology Process of 5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil

There total 4 articles about 5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14036-89-6,17014-74-3
5-amino-6-(D-ribitylamino)uracil

: (3-chlorocarbonyl-propyl)-phosphonic acid dibenzyl ester

: 474644-27-4
5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil

Guidance literature:: With triethylamine; In water; acetonitrile; at 20 ℃; for 12h;
DOI:10.1021/jo020144r

Reference yield:

: 17176-77-1
Dibenzyl phosphite

: 474644-27-4
5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 60 °C

1.2: 28 percent / tetrahydrofuran / Heating

2.1: 81 percent / LiOH*H₂O / H₂O; tetrahydrofuran / 1 h / 20 °C

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

4.1: 0.5 g / Et₃N / acetonitrile; H₂O / 12 h / 20 °C

With lithium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jo020144r

Reference yield:

: 212780-49-9
4-(dibenzylphosphonyl)butanoic acid

: 474644-27-4
5-(4-dibenzylphosphonobutyryl)amino-6-D-ribitylaminouracil

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

2: 0.5 g / Et₃N / acetonitrile; H₂O / 12 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water; acetonitrile;
DOI:10.1021/jo020144r