Technology Process of 5-fluoro-1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline
There total 4 articles about 5-fluoro-1-isopropyl-6-methoxy-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride; acetic acid;
In
dichloromethane;
at 20 ℃;
for 15h;
Cooling with ice;
DOI:10.1248/cpb.59.1029
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sodium tetrahydroborate / ethanol / 2 h / 20 °C
2: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Cooling with ice
3: ethanol; water / 16 h / 70 °C
4: ammonium hydroxide; hydrogen / ethanol / 15 h / 20 °C
5: pyridine / 16 h / 20 °C / Cooling with ice
6: phosphorus pentoxide; trichlorophosphate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / Reflux
7: sodium tetrahydroborate / ethanol / 2 h / 20 °C / Cooling with ice
8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C
9: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice
10: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice
With
hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; carbon tetrabromide; phosphorus pentoxide; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trichlorophosphate;
In
pyridine; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
6: Bischler-Napieralski reaction;
DOI:10.1248/cpb.59.1029
- Guidance literature:
-
Multi-step reaction with 9 steps
1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Cooling with ice
2: ethanol; water / 16 h / 70 °C
3: ammonium hydroxide; hydrogen / ethanol / 15 h / 20 °C
4: pyridine / 16 h / 20 °C / Cooling with ice
5: phosphorus pentoxide; trichlorophosphate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / Reflux
6: sodium tetrahydroborate / ethanol / 2 h / 20 °C / Cooling with ice
7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C
8: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice
9: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice
With
hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; carbon tetrabromide; phosphorus pentoxide; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trichlorophosphate;
In
pyridine; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
5: Bischler-Napieralski reaction;
DOI:10.1248/cpb.59.1029
