N-[(1R,2R)-2-Hydroxycyclohexyl]butanamide

Base Information

Chemical Name:N-[(1R,2R)-2-Hydroxycyclohexyl]butanamide
CAS No.:134108-77-3
Molecular Formula:C10H19NO2
Molecular Weight:185.266
Hs Code.:
DSSTox Substance ID:DTXSID801269833
Nikkaji Number:J357.188B
Mol file:134108-77-3.mol

Synonyms:SCHEMBL4341647;DTXSID801269833;134108-77-3;N-[(1R,2R)-2-Hydroxycyclohexyl]butanamide

Suppliers and Price of N-[(1R,2R)-2-Hydroxycyclohexyl]butanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-[(1R,2R)-2-Hydroxycyclohexyl]butanamide

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:185.141578849
Heavy Atom Count:13
Complexity:170

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCC(=O)NC1CCCCC1O
Isomeric SMILES:CCCC(=O)N[C@@H]1CCCC[C@H]1O

Technology Process of N-[(1R,2R)-2-Hydroxycyclohexyl]butanamide

There total 3 articles about N-[(1R,2R)-2-Hydroxycyclohexyl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5
(1R,2R)-2-aminocyclohexanol

: 141-75-3
butyryl chloride

: 134108-77-3
(1R,2R)-N-(2-hydroxycyclohexyl)butyramide

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1039/b412802h

Reference yield:

: 134070-86-3,134108-77-3
N-((1S,2S)-2-Hydroxy-cyclohexyl)-butyramide

: 134108-77-3
(1R,2R)-N-(2-hydroxycyclohexyl)butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / DMAP, pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 48 h / 25 °C / 0.1M phosphate buffer, pH 6.50, lipase P from Pseudomonas sp.

With pyridine; dmap; In dichloromethane;

Reference yield:

: 134071-01-5,134108-91-1
Butyric acid (1S,2S)-2-butyrylamino-cyclohexyl ester

: 823177-21-5
(1S,2S)-N-(2-hydroxycyclohexyl)butyramide

: 134108-77-3
(1R,2R)-N-(2-hydroxycyclohexyl)butyramide

Guidance literature:: at 25 ℃; for 48h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; 0.1M phosphate buffer, pH 6.50, lipase P from Pseudomonas sp.;