Technology Process of ND-478
There total 9 articles about ND-478 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; dichloromethane; ethyl acetate;
at 0 - 20 ℃;
for 48h;
Inert atmosphere;
DOI:10.1021/jm200566e
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thiourea / methanol; dichloromethane / 18 h / 20 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane; dichloromethane; ethyl acetate / 48 h / 0 - 20 °C / Inert atmosphere
3: 4-methyl-morpholine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling
4: hydrogenchloride / 1,4-dioxane; dichloromethane; ethyl acetate / 48 h / 0 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; hydrogenchloride; thiourea;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm200566e
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / methanol / 2 h / 60 °C / Inert atmosphere
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / Inert atmosphere; Cooling with ice
3: thiourea / methanol; dichloromethane / 18 h / 20 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane; dichloromethane; ethyl acetate / 48 h / 0 - 20 °C / Inert atmosphere
5: 4-methyl-morpholine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling
6: hydrogenchloride / 1,4-dioxane; dichloromethane; ethyl acetate / 48 h / 0 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; hydrogenchloride; triethylamine; thiourea; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm200566e
