4,4'-difluoro-2,2'-bipyridine

Base Information

• Chemical Name: 4,4'-difluoro-2,2'-bipyridine
• CAS No.: 1189458-67-0
• Molecular Formula: C₁₀H₆F₂N₂
• Molecular Weight: 192.168
• Mol file: 1189458-67-0.mol

Synonyms:

Chemical Property of 4,4'-difluoro-2,2'-bipyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4'-difluoro-2,2'-bipyridine

There total 4 articles about 4,4'-difluoro-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.5%

2-bromo-4-fluoro-pyridine (357927-50-5) → 4,4'-difluoro-2,2'-bipyridine (1189458-67-0)

Guidance literature:

With indium; palladium diacetate; lithium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejic.201500633

Reference yield: 36.0%

4,4'-diamino-2,2'-bipyridyl (18511-69-8) → 4,4'-difluoro-2,2'-bipyridine (1189458-67-0)

Guidance literature:

With pyridine hydrofluoride; sodium nitrite; In toluene; at -4 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.10.094

Reference yield: 29.0%

4,4'-dichloro-2,2'-bipyridine (1762-41-0) → 4,4'-difluoro-2,2'-bipyridine (1189458-67-0)

Guidance literature:

With tetramethylammonium fluoride; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.1c01490

upstream raw materials:

2-bromo-4-fluoro-pyridine

4,4'-diamino-2,2'-bipyridyl

Ethyl bromodifluoroacetate

4,4'-dichloro-2,2'-bipyridine

Refernces

• 1、 Bland, Douglas C.,Lee, So Jeong,Morales-Colón, Mariá T.,Sanford, Melanie S.,Scott, Peter J. H.,See, Yi Yang. "Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination". supporting information. p. 4493 - 4498. Retrieved 2021/06/28.
• 2、 Chadwick, Nina,Kumar, D. Kishore,Ivaturi, Aruna,Grew, Benjamin A.,Upadhyaya, Hari M.,Yellowlees, Lesley J.,Robertson, Neil. "Isomer Dependence of Efficiency and Charge Recombination in Dye-Sensitized Solar Cells Using Ru Complex Dyes Bearing Halogen Substituents". . p. 4878 - 4884. Retrieved 2015/11/02.