Technology Process of methyl 9-isopropyl-4-[(1E,3E)-4-(4-methoxyphenyl)buta-1,3-dien-1-yl]-6-methyl-1-[(1E,3E)-4-(4-nitrophenyl)buta-1,3-dien-1-yl]heptalene-5-carboxylate
There total 11 articles about methyl 9-isopropyl-4-[(1E,3E)-4-(4-methoxyphenyl)buta-1,3-dien-1-yl]-6-methyl-1-[(1E,3E)-4-(4-nitrophenyl)buta-1,3-dien-1-yl]heptalene-5-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; silver carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1002/hlca.201300137
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium iodide / acetone / 4 h / 20 °C
2.1: sodium hydroxide / dichloromethane; water / 12 h / 20 °C / Inert atmosphere
3.1: lithium hydroxide / methanol; water / 2 h / 70 °C
4.1: N,N-dimethyl-formamide; oxalyl dichloride / acetonitrile / 0 °C
4.2: 20 °C
5.1: diisobutylaluminium hydride / toluene / -78 °C
6.1: chromium dichloride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
7.1: palladium diacetate; silver carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
With
chromium dichloride; oxalyl dichloride; palladium diacetate; diisobutylaluminium hydride; N,N-dimethyl-formamide; silver carbonate; sodium iodide; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
2.1: |Wittig Olefination / 6.1: |Takai-Utimoto Olefination / 7.1: |Heck Reaction;
DOI:10.1002/hlca.201300137
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: toluene / 24 h / 130 °C
2.1: hexachloroethane; potassium tert-butylate / tetrahydrofuran / -78 °C / Inert atmosphere
3.1: sodium iodide / acetone / 1 h / 20 °C / Inert atmosphere
4.1: dichloromethane / 0.67 h / 90 - 100 °C / 300 - 450 Torr
5.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere
5.2: 12 h / -78 - 20 °C / Inert atmosphere
6.1: lithium hydroxide / methanol; water / 2 h / 70 °C
7.1: N,N-dimethyl-formamide; oxalyl dichloride / acetonitrile / 0 °C
7.2: 20 °C
8.1: diisobutylaluminium hydride / toluene / -78 °C
9.1: chromium dichloride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
10.1: palladium diacetate; silver carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
With
chromium dichloride; oxalyl dichloride; hexachloroethane; potassium tert-butylate; palladium diacetate; sodium hexamethyldisilazane; diisobutylaluminium hydride; N,N-dimethyl-formamide; silver carbonate; sodium iodide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
3.1: |Finkelstein Reaction / 4.1: |Michaelis-Arbuzov Synthesis / 5.1: |Horner-Wadsworth-Emmons Olefination / 5.2: |Horner-Wadsworth-Emmons Olefination / 9.1: |Takai-Utimoto Olefination / 10.1: |Heck Reaction;
DOI:10.1002/hlca.201300137
