Technology Process of (S)-7-bromo-3-methyl-2,3-dihydrooxazolo[3,2-b]indazole
There total 3 articles about (S)-7-bromo-3-methyl-2,3-dihydrooxazolo[3,2-b]indazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-Alaninol; 4-bromo-1-(bromomethyl)-2-nitrobenzene;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; isopropyl alcohol;
at 20 ℃;
for 36h;
With
potassium hydroxide;
In
tetrahydrofuran; water; isopropyl alcohol;
at 50 ℃;
for 10.5h;
DOI:10.1021/ol3015804
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 10 h / UV-irradiation; Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; isopropyl alcohol / 36 h / 20 °C
2.2: 10.5 h / 50 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; tetrachloromethane; isopropyl alcohol;
2.1: Davis-Beirut reaction;
DOI:10.1021/ol3015804
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen bromide / water / Heating
1.2: 0 - 2 °C
1.3: 0.5 h / 90 °C
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 10 h / UV-irradiation; Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; isopropyl alcohol / 36 h / 20 °C
3.2: 10.5 h / 50 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen bromide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; tetrachloromethane; water; isopropyl alcohol;
1.3: Sandmeyer reaction / 3.1: Davis-Beirut reaction;
DOI:10.1021/ol3015804
