C₃₈H₄₃FN₂O₉S₂

Base Information

• Chemical Name: C₃₈H₄₃FN₂O₉S₂
• CAS No.: 865135-77-9
• Molecular Formula: C₃₈H₄₃FN₂O₉S₂
• Molecular Weight: 754.898
• Mol file: 865135-77-9.mol

Synonyms:

Chemical Property of C₃₈H₄₃FN₂O₉S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₄₃FN₂O₉S₂

There total 13 articles about C₃₈H₄₃FN₂O₉S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-(4-{({4'-[2-(ethylsulfanyl)ethoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate (865135-76-8) → C38H43FN2O9S2 (865135-77-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In ethyl acetate; at 0 - 20 ℃;

DOI:10.1021/jm2016123

Reference yield:

(4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methanol (858096-63-6) → C38H43FN2O9S2 (865135-77-9)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0 - 20 °C

With tributylphosphine; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; diethylazodicarboxylate; In tetrahydrofuran; ethyl acetate; toluene;

DOI:10.1021/jm2016123

Reference yield:

tert-butyl 3-(2-fluoro-4-{[(4'-hydroxy-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}phenyl)propanoate (865135-75-7) → C38H43FN2O9S2 (865135-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0 - 20 °C

With tributylphosphine; 3-chloro-benzenecarboperoxoic acid; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jm2016123

upstream raw materials:

4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde

(4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methanol

4'-((tert-butyldimethylsilyl)oxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-carbaldehyde

tert-butyl 3-(4-{[(4'-{[tert-butyldimethylsilyl]oxy}-2',6'-dimethylbiphenyl-3-yl)methyl][(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate

Downstream raw materials:

C₃₂H₄₀FNO₅S

3-{4-[({4'-[2-(ethylsulfonyl)ethoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoic acid