4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

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Chemical Name:4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid
CAS No.:1562995-23-6
Molecular Formula:C₂₄H₁₇ClF₄N₄O₄
Molecular Weight:536.87
Hs Code.:

Synonyms:

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Chemical Property of 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

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Technology Process of 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

There total 14 articles about 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603122-84-5
[2-fluoro-4-(methoxycarbonyl)phenyl]boronic acid

: 1562995-23-6
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 12 h / 90 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 12 h

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: |Suzuki Coupling;

Reference yield:

: 911434-05-4
5-bromo-2-methyl-3-nitropyridine

: 1562995-23-6
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: iron; ammonium chloride / water; ethanol / 0.67 h / 90 °C

2.1: triethylamine / dichloromethane / 36 h / 0 - 20 °C

3.1: potassium acetate; acetic acid; acetic anhydride / chloroform / 0.25 h / 20 °C

3.2: 48 h / 40 - 60 °C

4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride; triethylamine / acetonitrile / 18 h / 100 °C / 15001.5 Torr

5.1: potassium hydroxide; iodine / N,N-dimethyl acetamide / 1 h

6.1: dmap; triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

7.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C

8.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

9.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 12 h / 90 °C

10.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

10.2: 12 h

11.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; iodine; potassium acetate; acetic anhydride; iron; sodium hydride; sodium carbonate; ammonium chloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; triethylamine; potassium hydroxide; palladium dichloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 8.1: |Suzuki Coupling;

Reference yield:

: 2376-00-3
2-chloro-6-(trifluoromethyl)benzoic acid

: 1562995-23-6
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

5.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 12 h / 90 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

6.2: 12 h

7.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium hydride; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 4.1: |Suzuki Coupling;