2376-00-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-(trifluoromethyl)benzaldehyde serves as an intermediate in the synthesis of a variety of pharmaceutical products. Its unique structure contributes to the development of new drugs, enhancing their therapeutic properties and effectiveness in treating different medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-6-(trifluoromethyl)benzaldehyde is utilized in the production of various agrochemical products. Its chemical properties make it suitable for the creation of compounds that can protect crops from pests and diseases, thereby increasing agricultural productivity.
Used in Material Science:
2-Chloro-6-(trifluoromethyl)be is also employed in the development of new materials, capitalizing on its chemical properties to engineer materials with specific characteristics required for various applications in industries such as electronics, automotive, and aerospace.
Used in Organic Synthesis:
2-Chloro-6-(trifluoromethyl)benzaldehyde is a key component in organic synthesis reactions, where it acts as a versatile building block for creating a wide array of organic compounds. Its reactivity and structural features facilitate the synthesis of complex organic molecules for use in research and commercial applications.

Upstream product

• 124-38-9 carbon dioxide 
• 98-15-7 3-chlorotrifluoromethylbenzene 
• 380611-49-4 [2-chloro-6-(trifluoromethyl)benzene]lithium 

Downstream Products

• 1562995-43-0 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dicyclopropylcarbamoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid 
• 1562995-90-7 methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dicyclopropylcarbamoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate 
• 1562995-89-4 methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(chlorocarbonyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate 
• 1562995-79-2 methyl 3-bromo-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indole-6-carboxylate 
• 1562995-31-6 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1,3-oxazinane-3-carbonyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid 
• 1562995-78-1 methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1,3-oxazinane-3-carbonyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate 
• 1562995-77-0 methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-((3-hydroxypropyl)carbamoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate 

Relevant academic research and scientific papers

METHOD FOR METAL-ORGANIC PRODUCTION OF ORGANIC INTERMEDIATE PRODUCTS BY MEANS OF ARYL LITHIUM-BASES

The invention relates to a method for the production of substituted aromatic compounds by producing lithium arylene and by reacting it with suitable electrophiles. The method comprises the following steps (step 1); an aryl lithium compound ( auxiliary base'') is initially produced by reacting a halogen aromatic compound with lithium metal; said compound is subsequently (step 2) reacted for deprotonation of the aromatic substrate in order to form the corresponding lithium aromatic compound which is subsequently (step 3) reacted with a corresponding electrophile to form the desired substituted aromatic compound, see page 2 of the description.

NOVEL PHENYLALANINE DERIVATIVE

The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to α4 integrin and therapeutic agents for various diseases concerning α4 integrin.

Reagent-modulated optional site selectivities: The metalation of o-, m- and p-halobenzotrifluorides

Chloro(trifluoromethyl)benzenes and bromo(trifluoromethyl)benzenes undergo deprotonation at a position adjacent to the single halogen substituent when treated with alkyllithiums (at -75°C) and, respectively, lithium 2,2,6,6-tetramethylpiperidide (at -100°C) in tetrahydrofuran. Positional ambiguities, if existing, can be exploited to establish optional site selectivities. Thus, butyllithium reacts with 1-chloro-3-(trifluoromethyl)benzene under hydrogen/metal interconversion at the 2-position whereas sec-butyllithium attacks exclusively the 6-position. The latter mode of regioselectivity is also exhibited by 1-bromo-3-(trifluoromethyl)benzene in the presence of lithium 2,2,6,6-tetramethylpiperidide, only 2-bromo-4-(trifluoromethyl)phenyllithium being produced. 2-Bromo-6-(trifluoromethyl)phenyllithium is directly inaccessible, but is formed when 2-bromo-3-(trifluoromethyl)phenyllithium, generated at -100°C, is allowed to isomerize at -75°C.

2-[(2',6'-Disubstituted-phenyl)-imino]-imidazolidines and salts thereof

Compounds of the formula STR1 wherein Z is 2-ETHYL-6-METHYL-PHENYL, 2,6-di-trifluoromethyl-phenyl, 2-chloro-6-trifluoromethyl-phenyl or 2-fluoro-6-trifluoromethyl-phenyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compoun