N-[(R)-2-Hydroxy-3-chloropropyl]phthalimide

Base Information

Chemical Name:N-[(R)-2-Hydroxy-3-chloropropyl]phthalimide
CAS No.:148857-44-7
Molecular Formula:C₁₁H₁₀ClNO₃
Molecular Weight:239.658
Hs Code.:
DSSTox Substance ID:DTXSID201184988
Nikkaji Number:J2.026.508F

Synonyms:DTXSID201184988;CS-0165458;N-[(R)-2-Hydroxy-3-chloropropyl]phthalimide;(R)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione;2-[(2R)-3-Chloro-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione;(R)-2-(3-Chloro-2-hydroxypropyl)isoindoline-1,3-dione (Rivaroxaban Impurity pound(c);148857-44-7

Suppliers and Price of N-[(R)-2-Hydroxy-3-chloropropyl]phthalimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-[(R)-2-Hydroxy-3-chloropropyl]phthalimide

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:239.0349209
Heavy Atom Count:16
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=O)N(C2=O)CC(CCl)O
Isomeric SMILES:C1=CC=C2C(=C1)C(=O)N(C2=O)C[C@H](CCl)O

Technology Process of N-[(R)-2-Hydroxy-3-chloropropyl]phthalimide

There total 4 articles about N-[(R)-2-Hydroxy-3-chloropropyl]phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 136918-14-4,85-41-6
phthalimide

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 5455-98-1
2-oxiranylmethylisoindole-1,3-dione

: 19667-37-9,34839-11-7,148857-42-5,148857-44-7
2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: With potassium fluoride on basic alumina; In 2-methyltetrahydrofuran; for 3h; chemoselective reaction; Inert atmosphere; Reflux;
DOI:10.1039/c0gc00113a

Reference yield: 21.0%

: 5455-98-1
2-oxiranylmethylisoindole-1,3-dione

: 104-88-1
4-chlorobenzaldehyde

: 19667-37-9,34839-11-7,148857-42-5,148857-44-7
2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione

: 6378-66-1
2-chloro-1-(4-chlorophenyl)ethanol

Guidance literature:: 2-oxiranylmethylisoindole-1,3-dione; 4-chlorobenzaldehyde; With Chloroiodomethane; In 2-methyltetrahydrofuran; at -78 ℃; for 0.0333333h;

With methyllithium; In 2-methyltetrahydrofuran; diethyl ether; at -78 ℃; for 1h;
DOI:10.1039/d0ob02407d