Technology Process of (6-methyl-2,8-dioxo-2,3,4,8-tetrahydro-1H-[1,7]naphthyridin-7-yl)-acetic acid benzyl ester
There total 7 articles about (6-methyl-2,8-dioxo-2,3,4,8-tetrahydro-1H-[1,7]naphthyridin-7-yl)-acetic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / CH2Cl2 / Heating
2: Dibal-H / CH2Cl2
3: (COCl)2; DMSO; Et3N
4: NaH / tetrahydrofuran
5: H2 / Pd/C / methanol / 55 °C
6: pyridinium hydrochloride / 0.08 h / 155 °C
7: Cs2CO3 / dimethylformamide
With
oxalyl dichloride; hydrogen; pyridine hydrochloride; sodium hydride; diisobutylaluminium hydride; caesium carbonate; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1: protection / 2: Reduction / 3: Oxidation / 4: Horner-Emmons reaction / 5: Reduction / 6: deprotection / 7: Alkylation;
DOI:10.1016/S0960-894X(00)00170-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaH / tetrahydrofuran
2: H2 / Pd/C / methanol / 55 °C
3: pyridinium hydrochloride / 0.08 h / 155 °C
4: Cs2CO3 / dimethylformamide
With
hydrogen; pyridine hydrochloride; sodium hydride; caesium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
1: Horner-Emmons reaction / 2: Reduction / 3: deprotection / 4: Alkylation;
DOI:10.1016/S0960-894X(00)00170-0
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Dibal-H / CH2Cl2
2: (COCl)2; DMSO; Et3N
3: NaH / tetrahydrofuran
4: H2 / Pd/C / methanol / 55 °C
5: pyridinium hydrochloride / 0.08 h / 155 °C
6: Cs2CO3 / dimethylformamide
With
oxalyl dichloride; hydrogen; pyridine hydrochloride; sodium hydride; diisobutylaluminium hydride; caesium carbonate; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1: Reduction / 2: Oxidation / 3: Horner-Emmons reaction / 4: Reduction / 5: deprotection / 6: Alkylation;
DOI:10.1016/S0960-894X(00)00170-0
