2-o-Tolyl-isobutyramide

Base Information

• Chemical Name: 2-o-Tolyl-isobutyramide
• CAS No.: 30568-35-5
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Mol file: 30568-35-5.mol

Synonyms:

Chemical Property of 2-o-Tolyl-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-o-Tolyl-isobutyramide

There total 2 articles about 2-o-Tolyl-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methylphenyl)-2-methylpropionitrile (30568-28-6) → 2-o-Tolyl-isobutyramide (30568-35-5)

Guidance literature:

With potassium hydroxide; In water; ethylene glycol; for 16h; Reflux;

DOI:10.1002/anie.201702512

Reference yield:

→ 2-o-Tolyl-isobutyramide (30568-35-5)

Guidance literature:

entspr. Nitril, H2SO4, H2O;

Reference yield:

2-o-Tolyl-isobutyramide (30568-35-5) + methyl iodide (74-88-4) → N,N,2-trimethyl-2-(o-tolyl)propanamide

Guidance literature:

2-o-Tolyl-isobutyramide; With sodium hydride; In tetrahydrofuran; mineral oil; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201702512

upstream raw materials:

2-(2-methylphenyl)-2-methylpropionitrile