(18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one

Base Information

• Chemical Name: (18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one
• CAS No.: 110815-17-3
• Molecular Formula: C₅₃H₇₀O₈S₂Si
• Molecular Weight: 927.351
• Mol file: 110815-17-3.mol

Synonyms:

Chemical Property of (18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one

There total 1 articles about (18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

15-(tert-Butyl-diphenyl-silanyloxy)-15-(3-vinyl-oxiranyl)-pentadecanoic acid (E)-6,6-bis-benzenesulfonyl-hex-4-enyl ester (110815-15-1) → (18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one (110815-17-3)

Guidance literature:

With n-butyllithium; palladium diacetate; triisopropyl phosphite; Product distribution; further catalysts;

DOI:10.1016/S0040-4039(00)85303-4

Reference yield:

(18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one (110815-17-3) → (17E,19E,21E,23E)-16-(tert-Butyl-diphenyl-silanyloxy)-oxacyclohexacosa-17,19,21,23-tetraen-2-one (110838-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) Na(Hg) / 1.) DMAP / 1.) pyridine, room temp., 2.) THF, methanol, AcOH, 0 grad C

2: n-BuLi, Et₃N / Pd(OAc)2, dppb / toluene / 4.5 h / Heating

With n-butyllithium; sodium amalgam; triethylamine; dmap; palladium diacetate; 1,4-di(diphenylphosphino)-butane; In toluene;

DOI:10.1016/S0040-4039(00)85303-4

Reference yield:

(18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-oxacyclohexacosa-18,22-dien-2-one (110815-17-3) → (18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-oxacyclohexacosa-18,22-diene-2,17-dione (110815-18-4)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)85303-4

upstream raw materials:

15-(tert-Butyl-diphenyl-silanyloxy)-15-(3-vinyl-oxiranyl)-pentadecanoic acid (E)-6,6-bis-benzenesulfonyl-hex-4-enyl ester

Downstream raw materials:

Acetic acid (5E,9E)-7-benzenesulfonyl-12-(tert-butyl-diphenyl-silanyloxy)-26-oxo-oxacyclohexacosa-5,9-dien-11-yl ester

(18E,22E)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-oxacyclohexacosa-18,22-diene-2,17-dione

(17E,19E,21E,23E)-16-(tert-Butyl-diphenyl-silanyloxy)-oxacyclohexacosa-17,19,21,23-tetraen-2-one