5-(4-chloro-phenyl)-cyclooctanone

Base Information

• Chemical Name: 5-(4-chloro-phenyl)-cyclooctanone
• CAS No.: 107625-22-9
• Molecular Formula: C₁₄H₁₇ClO
• Molecular Weight: 236.741
• Mol file: 107625-22-9.mol

Synonyms:

Chemical Property of 5-(4-chloro-phenyl)-cyclooctanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-chloro-phenyl)-cyclooctanone

There total 10 articles about 5-(4-chloro-phenyl)-cyclooctanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-chloro-phenyl)-nonanedinitrile (100955-06-4) → 5-(4-chloro-phenyl)-cyclooctanone (107625-22-9)

Guidance literature:

With tetrahydrofuran; diethyl ether; lithium N-methylanilide; Erhitzen des Reaktionsprodukts mit wss. H₂SO₄;

DOI:10.1021/ja01530a050

Reference yield:

3-(4-chlorophenyl)pentane-1,5-dioic acid (35271-74-0) → 5-(4-chloro-phenyl)-cyclooctanone (107625-22-9)

Guidance literature:

Multi-step reaction with 9 steps

2: LiAlH₄; diethyl ether

3: hydrogen bromide / 120 - 130 °C

5: H₂SO₄

6: LiAlH₄; diethyl ether

7: hydrogen bromide / 130 °C

9: lithium-<N-methyl-anilide>; diethyl ether; THF / Erhitzen des Reaktionsprodukts mit wss. H₂SO₄

With tetrahydrofuran; lithium aluminium tetrahydride; diethyl ether; sulfuric acid; hydrogen bromide; lithium N-methylanilide;

DOI:10.1021/ja01530a050

Reference yield:

1,5-dibromo-3-(4-chloro-phenyl)-pentane (100126-12-3) → 5-(4-chloro-phenyl)-cyclooctanone (107625-22-9)

Guidance literature:

Multi-step reaction with 6 steps

2: H₂SO₄

3: LiAlH₄; diethyl ether

4: hydrogen bromide / 130 °C

6: lithium-<N-methyl-anilide>; diethyl ether; THF / Erhitzen des Reaktionsprodukts mit wss. H₂SO₄

With tetrahydrofuran; lithium aluminium tetrahydride; diethyl ether; sulfuric acid; hydrogen bromide; lithium N-methylanilide;

DOI:10.1021/ja01530a050

upstream raw materials:

5-(4-chloro-phenyl)-nonanedinitrile

3-(4-chlorophenyl)pentane-1,5-dioic acid

1,5-dibromo-3-(4-chloro-phenyl)-pentane

3-(4-chlorophenyl)pentane-1,5-diol